2024
DOI: 10.1002/nep3.67
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Liver enzyme and risk of vascular dementia: A univariable and multivariable Mendelian randomization of European descent

Jieyu Chen,
Jianzhun Chen,
Chunyu Liang
et al.

Abstract: BackgroundObservational studies have indicated a link between liver enzymes and dementia, but the causal relationship remains uncertain. We conducted a two‐sample Mendelian randomization (MR) study to investigate potential causal links between liver function markers (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], and γ‐glutamyltransferase [GGT]) and various forms of dementia (all‐cause dementia, Alzheimer's disease [AD], vascular dementia [VaD], and frontotemporal… Show more

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