Liver Enzyme Elevations Within 3 Months of Diagnosis of Inflammatory Bowel Disease and Likelihood of Liver Disease

Abstract

Elevation of both ALT and GGT within 90 days after the diagnosis of IBD is associated with a markedly increased likelihood of IBD-LD. Both ALT and GGT levels should be measured in all of the pediatric patients newly diagnosed as having IBD.

Clinical Features and Risk Factors of Autoimmune Liver Involvement in Pediatric Inflammatory Bowel Disease

“…15 most helpful diagnostic tool in the identification of IBD-associated AILD. 30 In 4% of cases liver enzymes were normal at the time of AILD diagnosis but hepatobiliary abnormalities were found at imaging.…”

Hepatobiliary manifestations of inflammatory bowel disease in children

“…Although numerous studies about hepatobiliary manifestations in inflammatory bowel disease (IBD) in adults have been published, data concerning the pediatric population are still insufficient. The diagnosis of hepatic disorders often starts with abnormal liver enzyme tests, which have been found in up to 40% of pediatric patients with IBD [1-3]. The association between an increased likelihood of IBD-liver disease and elevation of alanine aminotransferase (ALT) and glutamyl transpeptidase (GGT) activities within 90 days’ follow-up after the diagnosis of IBD was reported [3].…”

Abnormal Liver Biochemistry Is Common in Pediatric Inflammatory Bowel Disease

“…The Pediatric IBD Collaborative Research Group Registry recently reported significant associations between elevated LEs at the time of IBD diagnosis and chronic liver disease. 9 However, this study was limited to only an evaluation of LEs in the first 3 months after IBD diagnosis.…”