Liver Enzymes and Hepatic Histomorphological Assessment in Alloxan Monohydrate Induced Hyperglycaemic Male Wistar Rats treated with Theophylline

Abstract

Aim:Increase in blood glucose level has been associated with beta cells destruction which is enhanced by lipid peroxidation and hepatocellular damage. The present study was designed to investigate the effect of oral administration of theophylline on Liver enzymes (ALT, AST and ALP) and Liver histology in alloxan-induced diabetic male wistar rats. Study Design: This is an experimental study. Thirty healthy male wistar rats weighing between 160-180 g were grouped into five of six animals each (n=6) following the induction hyperglycaemia using Original Research Article