Liver Enzymes, Type 2 Diabetes, and Metabolic Syndrome in Middle-Aged, Urban Chinese Men

Villegas, Raquel; Xiang, Yong Bing; Elasy, Tom A.; Cai, Qiuyin; Wang, Xu; Li, Honglan; Fazio, Sergio; Linton, MacRae F.; Raiford, David S.; Wang, Zheng; Shu, Xiao Ou

doi:10.1089/met.2011.0016

Cited by 30 publications

(27 citation statements)

References 29 publications

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“…Finally, several reports indicate the existence of an association between elevated serum levels of liver enzymes and T2D [42,43]. According to previous data reporting beneficial effects of olive oil consumption on fatty liver [44,45], the decreased levels of AST and ALT, indirect circulating markers of liver injury, seem to be a further positive response to the HP-EVOO consumption in our subjects.…”

Section: Discussionsupporting

confidence: 68%

Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin

Santangelo

Filesi

Varı̀

et al. 2016

J Endocrinol Invest

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Section: Discussionsupporting

confidence: 68%

Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin

Santangelo

Filesi

Varı̀

et al. 2016

J Endocrinol Invest

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“…They predicted the involvement of liver injury associated with obesity and type II diabetes. 31 Similar observations were also concluded from a study conducted in Thailand among Thai adults.…”

Section: Discussionsupporting

confidence: 79%

Is it important to analyse serum liver enzymes in patients with established metabolic syndrome? A Pilot study to tie the knot

Maiti¹,

Kumar²

2017

Asian J Med Sci

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Background: Metabolic Syndrome (MetS) is one of the emerging health problems which is the major area of concern as it is not only a potential risk factor for some many diseases but it also affecting globally. It is a common multi-factorial disorder of metabolic derangements and prominent etiological factors for the development and progression of atherosclerotic vascular disease and type 2 diabetes. The relation between elevated serum gamma-glutamyl tranferase and metabolic syndrome, however, have been not well explored in a developing country like India. Aims and Objectives: The current study was designed to estimate the levels of alanine transaminase (ALT), aspartate transaminase (AST), and gamma-glutamyl transferase (GGT) in metabolic syndrome patients with age-sex matched healthy controls. Furthermore the relation of liver function status with the various biochemical parameters of metabolic syndrome was explored. Materials and Methods: In this present only patients of metabolic syndrome were selected based on inclusion and exclusion criteria of selecting cases. All the biochemical parameters were analysed using standard methods. Data collected were analysed using Statistical Package for the Social Sciences (version 20.0). P value (p<0.05) was considered to be significant. Results: Of the 200 cases and controls selected, the differences in serum GGT (p<0.001) and ALT (p=0.048) were statistically significant. In case of male subjects, study and controls groups were compared only for serum GGT level (p=0.032) and in case of female subjects, study and controls were compared for serum ALT (p=0.027) and serum GGT level (p<0.001)and the differences were found to be highly significant. When male and female subjects of study group were compared, significant differences were observed in their serum ALT and GGT levels. Conclusion: Patients suspected of metabolic syndrome must also get their liver profile enzymes analysed as liver function is also affected with metabolic syndrome and it could be an additional risk factor additive of metabolic syndrome. Early detection and management can be preventive and can have a better treatment modalities is managing patients with metabolic syndrome. It not only prevent disease progression but also prevents additional cost burden beard by the patients.

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“…MS, defined as a constellation of interrelated metabolic abnormalities, is prevalent in China. MS prevalence has been reported to be from 6.6% to 25.6% in the Chinese population891516, while the latest report showed that this figure jumped to 33.9%3. The key mechanisms of MS were related with insulin resistance, obesity, chronic low-grade systemic inflammation, endothelial dysfunction, etc.…”

Section: Discussionmentioning

confidence: 99%

Association between liver function and metabolic syndrome in Chinese men and women

Wang

Zhang

Zhu

et al. 2017

Sci Rep

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Metabolic syndrome (MS) could be associated with liver function. Our study aimed to investigate the association between liver function and MS in a large cohort of Chinese men and women. We enrolled 32,768 ostensibly healthy participants. The associations between liver function and MS of both genders were analyzed separately after dividing total bilirubin (TBIL), gamma glutamyltransferase (GGT), alanine aminotransferase (ALT) into quartiles. Young males had significantly higher MS prevalence than females, yet after menopause, females had higher MS prevalence. We used TBIL, GGT and ALT quartiles as categorical variables in binary logistic regression models. Significantly decreased MS risks were demonstrated in TBIL quartiles 2 to 4 for males, and quartiles 3 to 4 for females. As to GGT and ALT, significantly increased MS risks were shown in high quartiles for both genders. Aging also resulted in significantly higher MS risks in both genders except for young females. This study displayed close associations between liver function and MS, which were influenced by gender and age. A high TBIL level had protective effect against MS, while high GGT and ALT levels were risk factors for MS. It is meaningful that liver function is used as clinical risk predictors for MS.

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Liver Enzymes, Type 2 Diabetes, and Metabolic Syndrome in Middle-Aged, Urban Chinese Men

Cited by 30 publications

References 29 publications

Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin

Consumption of extra-virgin olive oil rich in phenolic compounds improves metabolic control in patients with type 2 diabetes mellitus: a possible involvement of reduced levels of circulating visfatin

Is it important to analyse serum liver enzymes in patients with established metabolic syndrome? A Pilot study to tie the knot

Association between liver function and metabolic syndrome in Chinese men and women

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