2019
DOI: 10.1007/s00403-019-01917-w
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Liver fatty acid-binding protein might be a predictive marker of clinical response to systemic treatment in psoriasis

Abstract: Fatty acid-binding proteins play an inconclusive role in lipid metabolism and cardiometabolic diseases (CMDs) which are closely related with psoriasis. Aim of the study was to investigate the diagnostic value of serum liver fatty acid-binding protein (FABP1) level and associations with disease severity, inflammation or metabolic parameters and influence of systemic treatment in psoriatic patients. The study included thirty-three patients with active plaque-type psoriasis and eleven healthy volunteers. Blood sa… Show more

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Cited by 11 publications
(21 citation statements)
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“…FABP1 (liver FABP) and FABP4 (adipocyte FABP) have been proved by our team of dermatologists to be significantly elevated in the serum of psoriatic patients and might be predictive markers of clinical response to systemic treatment [ 52 , 53 ], whereas FABP3 (muscle and heart FABP) seems not to be significantly increased in this group of patients [ 54 ]. FABP2 (intestinal FABP), which is a marker of enterocyte damage, has been proved to be elevated in the plasma of psoriatic patients [ 55 ].…”
Section: Aberrations In Lipid Metabolism In Psoriatic Patientsmentioning
confidence: 99%
“…FABP1 (liver FABP) and FABP4 (adipocyte FABP) have been proved by our team of dermatologists to be significantly elevated in the serum of psoriatic patients and might be predictive markers of clinical response to systemic treatment [ 52 , 53 ], whereas FABP3 (muscle and heart FABP) seems not to be significantly increased in this group of patients [ 54 ]. FABP2 (intestinal FABP), which is a marker of enterocyte damage, has been proved to be elevated in the plasma of psoriatic patients [ 55 ].…”
Section: Aberrations In Lipid Metabolism In Psoriatic Patientsmentioning
confidence: 99%
“…Serum FABP-4 levels are inversely correlated with serum TARC levels, which is possibly related to psoriasis remission [ 198 , 199 ]. Moreover, serum FABP-1 (liver-FABP) levels increase in cases of psoriasis depending on skin lesion severity [ 200 ], and FABP-2 (intestinal FABP) potentially reflects the subclinical disruption of the intestinal barrier in severe psoriasis cases [ 201 ].…”
Section: Biomarkers In Psoriasis Treatmentmentioning
confidence: 99%
“…Different components of the FABP family are expressed most abundantly in organs involved in active lipid metabolism. FABP isoforms are believed to be a useful tool of organ damage prediction and they play an important role in the development of a number of immunometabolic diseases [47][48][49]. For instance, heart-type FABP (FABP3) is a sensitive marker of acute myocardial infarction and predictor of heart failure among patients with coexisting metabolic syndrome, and its level is increased in diabetes mellitus.…”
Section: Fatty Acid Binding Proteinsmentioning
confidence: 99%
“…Białka z rodziny FABP ulegają ekspresji głównie w narządach uczestniczących w czynnym metabolizmie lipidów. Wykazano także, że izoformy FABP są przydatnym czynnikiem prognostycznym uszkodzenia narządów i mają duże znaczenie w rozwoju wielu chorób o podłożu immunometabolicznym [47][48][49]. Sercowe białko wiążące kwasy tłuszczowe (heart-FABP, H-FABP, FABP3) jest czułym markerem ostrego zawału mięśnia sercowego i predyktorem niewydolności serca u pacjentów ze współistniejącym zespołem metabolicznym, a jego stężenie wzrasta u osób chorych na cukrzycę.…”
Section: Białka Wiążące Kwasy Tłuszczoweunclassified