Liver Fibrosis Assessment by Viewing Sinusoidal Capillarization: US                     Molecular Imaging versus Two-dimensional Shear-Wave Elastography in                     Rats

Miao, Xiaoyan; Sha, Tingting; Zhang, Wei; Zhou, Honghang; Qiu, Chen; Deng, Huan; You, Yujia; Ren, Jie; Zhang, Xinling; Zheng, Rongqin; Yin, Tinghui

doi:10.1148/radiol.212325

Cited by 8 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LS is commonly used to noninvasively evaluate liver fibrosis. However, the accuracy of measuring liver fibrosis can be compromised by inflammation, especially when ALT concentrations are increased[ 25 ]. In the present study, we found that liver condition, which is affected by both liver fibrosis and inflammation, was positively correlated with LS; this finding is consistent with those of previous studies[ 5 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients: Hepatitis B virus infection and transaminases should be considered

Huang,

Peng,

Long

et al. 2024

World J Hepatol

View full text Add to dashboard Cite

BACKGROUND Liver condition is a crucial prognostic factor for patients with hepatocellular carcinoma (HCC), but a convenient and comprehensive method to assess liver condition is lacking. Liver stiffness (LS) measured by two-dimensional shear wave elastography may help in assessing liver fibrosis and liver condition. Chronic hepatitis B (CHB) is an important risk factor for HCC progression, but LS was found to be less reliable in assessing liver fibrosis following hepatitis viral eradication. We hypothesize that the status of hepatitis virus infection would affect the accuracy of LS in assessing the liver condition. AIM To test the feasibility and impact factors of using LS to assess liver condition in patients with HCC and CHB. METHODS A total of 284 patients were retrospectively recruited and classified into two groups on the basis of serum CHB virus hepatitis B virus (HBV)-DNA levels [HBV-DNA ≥ 100.00 IU/mL as Pos group (n = 200) and < 100.00 IU/mL as Neg group (n = 84)]. Correlation analyses and receiver operating characteristic analyses were conducted to evaluate the relationship between LS and liver condition. RESULTS A significant correlation was found between LS and most of the parameters considered to have the ability to evaluate liver condition (P < 0.05). When alanine aminotransferase (ALT) concentrations were normal (≤ 40 U/L), LS was correlated with liver condition indices (P < 0.05), but the optimal cutoff of LS to identify a Child-Pugh score of 5 was higher in the Neg group (9.30 kPa) than the Pos group (7.40 kPa). When ALT levels were elevated (> 40 U/L), the correlations between LS and liver condition indices were not significant (P > 0.05). CONCLUSION LS was significantly correlated with most liver condition indices in patients with CHB and HCC. However, these correlations varied according to differences in HBV-DNA and transaminase concentrations.

show abstract

Section: Discussionmentioning

confidence: 99%

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients: Hepatitis B virus infection and transaminases should be considered

Huang,

Peng,

Long

et al. 2024

World J Hepatol

View full text Add to dashboard Cite

show abstract

“…In contrast, the contrast intensity after the destruction was from re‐perfused free‐circulating microbubbles only 18,19 . The quantification of the targeting contrast signal was calculated as the normalized intensity differences (NIDs [%]) = (pre‐destruction contrast intensity − post‐destruction contrast intensity)/pre‐destruction contrast intensity × 100%] 20 …”

Section: Methodsmentioning

confidence: 99%

“… 18 , 19 The quantification of the targeting contrast signal was calculated as the normalized intensity differences (NIDs [%]) = (pre‐destruction contrast intensity − post‐destruction contrast intensity)/pre‐destruction contrast intensity × 100%]. 20 …”

Section: Methodsmentioning

confidence: 99%

Ultrasound molecular imaging for early detection of acute renal ischemia–reperfusion injury

Ren,

Zhao,

Wang

et al. 2024

Bioengineering & Transla Med

View full text Add to dashboard Cite

BackgroundMicrocirculatory perfusion disorder and inflammatory response are critical links in acute kidney injury (AKI). We aim to construct anti‐vascular cell adhesion molecule‐1(VCAM‐1) targeted microbubbles (TM) to monitor renal microcirculatory perfusion and inflammatory response.MethodsTM carrying VCAM‐1 polypeptide was constructed by biological coupling. The binding ability of TM to human umbilical vein endothelial cells (HUVECs) was detected. Bilateral renal ischemia–reperfusion injury (IRI) models of mice were established to evaluate microcirculatory perfusion and inflammatory response using TM. Thirty‐six mice were randomly divided into six groups according to the different reperfusion time (0.5, 2, 6, 12, and 24 h) and sham‐operated group (Sham group). The correlation of TM imaging with serum and histopathological biomarkers was investigated.ResultsTM has advantages such as uniform distribution, regular shape, high stability, and good biosafety. TM could bind specifically to VCAM‐1 molecule expressed by tumor necrosis factor‐alpha (TNF‐α)‐treated HUVECs. In the renal IRI‐AKI model, the area under the curve (AUC) of TM significantly decreased both in the renal cortical and medullary after 2 h of reperfusion compared with the Sham group (p < 0.05). Normalized intensity difference (NID) of TM at different reperfusion time was all higher than that of blank microbubbles (BM) and the Sham group (p < 0.05). Ultrasound molecular imaging of TM could detect AKI early before commonly used renal function markers, histopathological biomarkers, and BM imaging. AUC of TM was negatively correlated with serum creatinine (Scr), blood urea nitrogen (BUN), and Cystatin C (Cys‐C) levels, and NID of TM was linearly correlated with VCAM‐1, TNF‐α, and interleukin‐6 (IL‐6) expression (p < 0.05).ConclusionsUltrasound molecular imaging based on TM carrying VCAM‐1 polypeptide can accurately evaluate the changes in renal microcirculatory perfusion and inflammatory response, which might be a promising modality for early diagnosis of AKI.

show abstract

“…Molecular imaging was first proposed in 1999 by Professor Weissleder from Harvard University at the International Imaging Conference held in Mississippi. Just as the name implies, molecular imaging can reflect changes at the molecular and subcellular level in vivo and conduct qualitative and quantitative research on biological behaviors ( Duan et al, 2022 ), which has been widely employed in the diagnosis and therapeutic applications of a variety of diseases ( Hughes et al, 2022 ; Miao et al, 2022 ), including atherosclerosis. Characteristics of vulnerable plaque, such as angiogenesis, inflammation, necrotic core, intraplaque hemorrhage, thin fibrous cap, and microcalcification can be assayed ( Bala and Cosyns, 2014 ; Dweck et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Pan

Chen

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Background: Cardiovascular and cerebrovascular diseases are major global health problems, and the main cause is atherosclerosis. Recently, molecular imaging has been widely employed in the diagnosis and therapeutic applications of a variety of diseases, including atherosclerosis. Substantive facts have announced that molecular imaging has broad prospects in the early diagnosis and targeted treatment of atherosclerosis.Objective: We conducted a scientometric analysis of the scientific publications over the past 23 years on molecular imaging research in atherosclerosis, so as to identify the key progress, hotspots, and emerging trends.Methods: Original research and reviews regarding molecular imaging in atherosclerosis were retrieved from the Web of Science Core Collection database. Microsoft Excel 2021 was used to analyze the main findings. CiteSpace, VOSviewer, and a scientometric online platform were used to perform visualization analysis of the co-citation of journals and references, co-occurrence of keywords, and collaboration between countries/regions, institutions, and authors.Results: A total of 1755 publications were finally included, which were published by 795 authors in 443 institutions from 59 countries/regions. The United States was the top country in terms of the number and centrality of publications in this domain, with 810 papers and a centrality of 0.38, and Harvard University published the largest number of articles (182). Fayad, ZA was the most productive author, with 73 papers, while LIBBY P had the most co-citations (493). CIRCULATION was the top co-cited journal with a frequency of 1,411, followed by ARTERIOSCL THROM VAS (1,128). The co-citation references analysis identified eight clusters with a well-structured network (Q = 0.6439) and highly convincing clustering (S = 0.8865). All the studies calculated by keyword co-occurrence were divided into five clusters: “nanoparticle,” “magnetic resonance imaging,” “inflammation,” “positron emission tomography,” and “ultrasonography”. Hot topics mainly focused on cardiovascular disease, contrast media, macrophage, vulnerable plaque, and microbubbles. Sodium fluoride ⁃PET, targeted drug delivery, OCT, photoacoustic imaging, ROS, and oxidative stress were identified as the potential trends.Conclusion: Molecular imaging research in atherosclerosis has attracted extensive attention in academia, while the challenges of clinical transformation faced in this field have been described in this review. The findings of the present research can inform funding agencies and researchers toward future directions.

show abstract

Liver Fibrosis Assessment by Viewing Sinusoidal Capillarization: US Molecular Imaging versus Two-dimensional Shear-Wave Elastography in Rats

Cited by 8 publications

References 34 publications

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients: Hepatitis B virus infection and transaminases should be considered

Liver stiffness in hepatocellular carcinoma and chronic hepatitis patients: Hepatitis B virus infection and transaminases should be considered

Ultrasound molecular imaging for early detection of acute renal ischemia–reperfusion injury

Molecular imaging research in atherosclerosis: A 23-year scientometric and visual analysis

Contact Info

Product

Resources

About