Liver fibrosis in chronic viral hepatitis: An ultrasonographic study

Zheng, Rongqin; Wang, Qinghui; Lu, Ming-De; Xie, Shi-Bin; Ren, Jie; Su, Zhongzhen; Cai, Yin-Ke; Yao, Ji‐Jin

doi:10.3748/wjg.v9.i11.2484

Cited by 49 publications

(32 citation statements)

References 20 publications

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“…Hung et al [21] evaluated the validity of US in diagnosis of cirrhosis with a diagnostic sensitivity of liver cirrhosis of 0.775 and a specificity of 0.92 in patients with HBV infection. Zheng et al [22] studied the value of US in evaluation of liver fibrosis and compensated cirrhosis in comparison with serology and histology and found that hepatic parenchymal echo pattern, liver surface and thickness of gallbladder wall are three independent predictors of liver fibrosis. The diagnostic accuracy of US for compensated cirrhosis is 80.7%.…”

Section: Discussionmentioning

confidence: 99%

Correlation between ultrasonographic and pathologic diagnosis of liver fibrosis due to chronic virus hepatitis

Shen

Li²,

Zeng³

et al. 2006

WJG

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INTRODUCTIONChronic hepatitis virus B or C infection results in damage to hepatocytes and may eventually lead to liver fibrosis, cirrhosis and/or hepatocellular carcinoma [1][2][3] . The diagnosis of liver fibrosis and cirrhosis in patients with chronic virus hepatitis is of therapeutic and prognostic importance.Although histologic examination of percutaneous biopsy specimens is the gold criterion for the severity of fibrosis and cirrhosis, biopsy is invasive and cannot be used repeatedly in follow-up. Moreover, liver biopsy can yield false negative results in nearly 20-30% of cases [4][5][6][7] . Therefore, it is important to use noninvasive methods in differentiation between liver fibrosis and cirrhosis.Ultrasonography (US) is a noninvasive and inexpensive procedure for diagnosis of focal and diffuse parenchymal disease of liver. Although US cannot detect minute changes, it can show liver cirrhosis in patients with decompensated liver function [8][9][10][11] . However, correlation between US and histologic diagnosis has not been fully investigated in large series of patients. We conducted a prospective study to evaluate the validity of US for diagnosis of liver fibrosis in patients with chronic liver hepatitis without clinical or biochemical evidence of cirrhosis. Abstract AIM: To evaluate the validity of ultrasonographic and pathologic diagnosis of liver fibrosis in patients with chronic viral hepatitis. MATERIALS AND METHODS Patients METHODS:The liver fibrosis status in 324 patients was evaluated by both needle biopsy and ultrasonography. Liver fibrosis was divided into S0 -S4 stages. S4 stage was designated as definite cirrhosis. The ultrasonographic examination included qualitative variables, description of liver surface and parenchyma, and quantitative parameters, such as diameter of vessels, blood flow velocity and spleen size.

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Section: Discussionmentioning

confidence: 99%

Correlation between ultrasonographic and pathologic diagnosis of liver fibrosis due to chronic virus hepatitis

Shen

Li²,

Zeng³

et al. 2006

WJG

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“…Hepatic fibrogenesis is often associated with hepatocellular necrosis and inflammation accompanied by repair processes [26,27] . Kupffer cells were shown to be a critical mediator of the inflammatory and fibrogenic responses during CCl 4 -mediated Yuan GJ et al Pioglitazone on rat hepatic fibrosi 1049 B A liver damages [28] .…”

Section: Discussionmentioning

confidence: 99%

Effects of PPARg agonist pioglitazone on rat hepatic fibrosis

Yuan¹,

Zhang²,

Gong³

2004

WJG

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“…Zhong and others observed that this increased thickness and echogenicity of the gall bladder walls is related to the progression of fibrosis in patients with chronic viral hepatitis. 27 In the population studied, a patent paraumbilical vein was seen in 2% of cases, which can be explained by a recent diagnosis. Most patients were asymptomatic.…”

Section: Assessment Of Fibrosis In Patients With Hepatitis Cmentioning

confidence: 99%

Non-Invasive Assessment of Fibrosis Using Color Doppler Ultrasound in Patients with Hepatitis C Virus in the Amazon Rainforest, Brazil

Leão

Brock²,

Castilho³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. The purpose of this study was to correlate morphologic and hemodynamic Doppler ultrasound findings as indicators of the degree of inflammation and fibrosis and to diagnose chronic vital hepatitis complications and progression. A prospective, descriptive study of a case series was conducted that analyzed Doppler ultrasound images of the liver and portal system and used the portal vein congestion index, hepatic and splenic artery impedance indices, and the liver vascular index. Of 50 patients positive for antibodies against hepatitis C virus, morphologic changes highlighted increased hepatic parenchyma echogenicity in 24%, and increased gall blander echogenicity and wall thickness in 4%. The most common hemodynamic changes observed were reduced flow velocity in the portal vein trunk in 26%, congestion index changes in 12%, liver vascular index changes in 16%, and splenic and hepatic artery impedance index changes in 14%. These indices were shown to be associated with alanine aminotransferase levels, which suggested that they are important liver damage indicators in the early phase of infection with hepatitis C virus.

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Liver fibrosis in chronic viral hepatitis: An ultrasonographic study

Cited by 49 publications

References 20 publications

Correlation between ultrasonographic and pathologic diagnosis of liver fibrosis due to chronic virus hepatitis

Correlation between ultrasonographic and pathologic diagnosis of liver fibrosis due to chronic virus hepatitis

Effects of PPARg agonist pioglitazone on rat hepatic fibrosis

Non-Invasive Assessment of Fibrosis Using Color Doppler Ultrasound in Patients with Hepatitis C Virus in the Amazon Rainforest, Brazil

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