Liver Fibrosis in Some Patients with Non-Alcoholic Fatty Liver Disease: from Diagnosis to Prognosis

Abstract

The purpose of this publication was to update knowledge about non-alcoholic fatty liver disease (NAFLD) and fibrogenesis, as well as factors that have a positive or negative prognostic value in relation to the formation and progression of liver fibrosis. This review article contains the current literature dates about pathogenetic factors of the development of liver fibrosis in NAFLD and conceptual ideas about its diagnosis at this moment. Obviously, along with genetic and epigenetic factors, hyper- and disproduction of organokines affect to the progression of the disease. Evaluation of the quantitative and qualitative composition of the microbiota, the integrity of the epithelial intestinal barrier are perceptual fields for research this problem. Non-invasive proprietary and non-proprietary scales for assessing the risk of steatosis and fibrosis, transient elastometry are suitable for routine assessment of individual risk of disease development and progression. This scientific review demonstrates proofs of necessity to develop individual strategies for the management of patients with NAFLD in relation to its metabolic activity and the stage of liver fibrosis.