Liver fibrosis stage based on the four factors (FIB-4) score or Forns index in adults with chronic hepatitis C

Huttman, Marc; Parigi, Tommaso Lorenzo; Zoncapè, Mirko; Liguori, Antonio; Kalafateli, Maria; Noel-Storr, Anna H; Casazza, Giovanni; Tsochatzis, Emmanuel

doi:10.1002/14651858.cd011929.pub2

Cochrane Database of Systematic Reviews

2024

DOI: 10.1002/14651858.cd011929.pub2

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Liver fibrosis stage based on the four factors (FIB-4) score or Forns index in adults with chronic hepatitis C

Marc Huttman,

Tommaso Lorenzo Parigi,

Mirko Zoncapè

et al.

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Inflammatory biomarkers as cost-effective predictive tools in metabolic dysfunction-associated fatty liver disease

Ramoni,

Liberale,

Montecucco

2024

World J Gastroenterol

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Qu and Li emphasize a fundamental aspect of metabolic dysfunction-associated fatty liver disease in their manuscript, focusing on the critical need for non-invasive diagnostic tools to improve risk stratification and predict the progression to severe liver complications. Affecting approximately 25% of the global population, metabolic dysfunction-associated fatty liver disease is the most common chronic liver condition, with higher prevalence among those with obesity. This letter stresses the importance of early diagnosis and intervention, especially given the rising incidence of obesity and metabolic syndrome. Research advancements provide insight into the potential of biomarkers (particularly inflammation-related) as predictive tools for disease progression and treatment response. This overview addresses pleiotropic biomarkers linked to chronic inflammation and cardiometabolic disorders, which may aid in risk stratification and treatment efficacy monitoring. Despite progress, significant knowledge gaps remain in the clinical application of these biomarkers, necessitating further research to establish standardized protocols and validate their utility in clinical practice. Understanding the complex interactions among these factors opens new avenues to enhance risk assessment, leading to better patient outcomes and addressing the public health burden of this worldwide condition.

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Inflammatory biomarkers as cost-effective predictive tools in metabolic dysfunction-associated fatty liver disease

Ramoni,

Liberale,

Montecucco

2024

World J Gastroenterol

View full text Add to dashboard Cite

show abstract

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Liver fibrosis stage based on the four factors (FIB-4) score or Forns index in adults with chronic hepatitis C

Cited by 1 publication

References 118 publications

Inflammatory biomarkers as cost-effective predictive tools in metabolic dysfunction-associated fatty liver disease

Inflammatory biomarkers as cost-effective predictive tools in metabolic dysfunction-associated fatty liver disease

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