Liver Flukes: Clonorchis and Opisthorchis

Saijuntha, Weerachai; Sithithaworn, Paiboon; Kaitsopit, Nadda; Andrews, Ross H.; Petney, Trevor N.

doi:10.1007/978-1-4939-0915-5_6

Cited by 28 publications

(16 citation statements)

References 228 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, they enhance our understanding of the carcinogenesis process ( 17 ). Molecular studies have focused specifically on characterizing the O. viverrini protein tegument and excretion–secretion products, which can provide defined molecular targets to treat infection, facilitate the development of new, rapid/cheap diagnostic tools which could break the transmission cycle, and potentially identify targets for vaccine development ( 7 ).…”

Section: Current Situationmentioning

confidence: 99%

Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia

et al. 2018

Self Cite

View full text Add to dashboard Cite

Similar to bile duct cancer or cholangiocarcinoma (CCA) in the western world, opisthorchiasis-associated CCA in Southeast Asia is an aggressive cancer with high mortality rates. It is known to cause a significant health burden in the opisthorchiasis region in Thailand and possibly throughout mainland Southeast. To reduce this health burden, a comprehensive prevention and control program for opisthorchiasis, as well as CCA, is required. In this review, our aim is to provide a brief update of the current situation regarding the natural history of opisthorchiasis and health burden of CCA in Southeast Asia. A comprehensive approach to tackling these issues being implemented in Thailand under the “Cholangiocarcinoma Screening and Care Program” is described. This comprehensive program consists of a three stage prevention and patient care program. The primary prevention component involves opisthorchiasis screening using a new and sensitive urine assay. The secondary prevention component involves screening for CCA and periductal fibrosis, with suspected CCA patients following the protocol for confirmation and appropriate treatment. Due to the eco-epidemiology of opisthorchiasis-induced CCA, the anticipated impacts and outcomes of the program include short-, medium-, and the long-term goals for the reduction of CCA incidence. To achieve long-term sustainable impacts, concerted efforts to raise social awareness and participating action by general public, non-government organizations, and government agencies are necessary. The strategic plans developed for this program can be expanded for use in other endemic areas as well as being a model for use in other chronic diseases.

show abstract

Section: Current Situationmentioning

confidence: 99%

Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Opisthorchis viverrini requires freshwater snails and cyprinid fish as first and second intermediate hosts, respectively, to complete its life cycle [ 5 ]. The prevalence of infection in the fish hosts is usually very high [ 6 ], whereas infection rates in the snail hosts are very low [ 7 , 8 ].…”

Section: Resultsmentioning

confidence: 99%

Seasonal cercarial emergence patterns of Opisthorchis viverrini infecting Bithynia siamensis goniomphalos from Vientiane Province, Lao PDR

et al. 2014

Self Cite

View full text Add to dashboard Cite

BackgroundSnail intermediate hosts play a pivotal role in maintaining the life cycles of trematodes, including Opisthorchis viverrini. We investigated the emergence patterns of O. viverrini cercariae infecting Bithynia siamensis goniomphalos at foci in an endemic area in Vientiane Province, Lao PDR.FindingsSamples of B. s. goniomphalos collected during the hot-dry, rainy and cool-dry seasons were examined for O. viverrini infection by cercarial shedding. Emergence of cercariae from O. viverrini-positive snails was monitored daily from 06:00–18:00 h for seven consecutive days at 2 hourly intervals. Snail infections varied seasonally, being highest in the cool-dry season. Peak cercarial emergence was not consistent in different seasons, occurring between 08.00–10.00 h during the hot-dry season and between 12.00–14.00 h during the rainy and cool-dry seasons. The cercarial output was highest in the hot-dry season. The prevalence of infection and the emergence of cercariae were strongly dependent on snail size.ConclusionsThis study shows that size of snails and environmental factors (such as season) may affect the emergence patterns of cercariae of O. viverrini in snails. These results have both fundamental and applied implications for opisthorchiasis epidemiology and control.

show abstract

“…The life-cycle involves freshwater Bithynia snail species as the first intermediate hosts, cyprinid fish as second intermediate hosts and humans as definitive hosts. Cats and dogs act as reservoir hosts (Saijuntha et al 2014). Humans are exposed by eating raw or partially cooked fish infected with viable metacercariae of O. viverrini (Grundy-Warr et al 2012; Sithithaworn and Haswell-Elkins 2003).…”

Section: Introductionmentioning

confidence: 99%

Preliminary genetic evidence of two different populations of Opisthorchis viverrini in Lao PDR

et al. 2017

Self Cite

View full text Add to dashboard Cite

Opisthorchis viverrini is a major public health concern in Southeast Asia. Various reports have suggested that this parasite may represent a species complex, with genetic structure in the region perhaps being dictated by geographical factors and different species of intermediate hosts. We used four microsatellite loci to analyze O. viverrini adult worms originating from six species of cyprinid fish in Thailand and Lao PDR. Two distinct O. viverrini populations were observed. In Ban Phai, Thailand, only one subgroup occurred, hosted by two different fish species. Both subgroups occurred in fish from That Luang, Lao PDR, but were represented to very different degrees among the fish hosts there. Our data suggest that, although geographical separation is more important than fish host specificity in influencing genetic structure, it is possible that two species of Opisthorchis, with little interbreeding, are present near Vientiane in Lao PDR.

show abstract

Liver Flukes: Clonorchis and Opisthorchis

Cited by 28 publications

References 228 publications

Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia

Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia

Seasonal cercarial emergence patterns of Opisthorchis viverrini infecting Bithynia siamensis goniomphalos from Vientiane Province, Lao PDR

Preliminary genetic evidence of two different populations of Opisthorchis viverrini in Lao PDR

Contact Info

Product

Resources

About