Liver function testing on the Abaxis Piccolo Xpress: Use in Ebola virus disease protocols

Owen, William E.; Caron, J; Genzen, Jonathan R.

doi:10.1016/j.cca.2015.03.044

Cited by 15 publications

(14 citation statements)

References 10 publications

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“…Few instruments available in the market provide liver function panels or lipid panel analysis; therefore, studies evaluating these devices are scarce. As expected, the detected levels of total protein were higher in LiHep whole blood than serum; this was attributed to the consumption of coagulation factors and fibrinogen during clotting . Correlation coefficients for liver function tests were similar to those reported by previous studies that compared measurements of LiHep whole blood, performed using the Abbott Piccolo Xpress, to those obtained in a central laboratory .…”

Section: Discussionsupporting

confidence: 87%

“…As expected, the detected levels of total protein were higher in LiHep whole blood than serum; this was attributed to the consumption of coagulation factors and fibrinogen during clotting . Correlation coefficients for liver function tests were similar to those reported by previous studies that compared measurements of LiHep whole blood, performed using the Abbott Piccolo Xpress, to those obtained in a central laboratory . However, when the % bias was compared, the data for amylase and GGT showed lower bias while those for the remaining analytes (AST, ALT, ALP, albumin, and total protein) showed higher bias than in other studies .…”

Section: Discussionsupporting

confidence: 85%

“…Correlation coefficients for liver function tests were similar to those reported by previous studies that compared measurements of LiHep whole blood, performed using the Abbott Piccolo Xpress, to those obtained in a central laboratory (19,20). However, when the % bias was compared, the data for amylase and GGT showed lower bias while those for the remaining analytes (AST, ALT, ALP, albumin, and total protein) showed higher bias than in other studies (19,20). In particular, when analyses were performed using whole blood samples, the data for AST exhibited a significant bias that exceeded the CLIA 88 requirement.…”

Section: Discussionsupporting

confidence: 83%

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Evaluation of the LABGEO PT10 Point‐Of‐Care Testing Device: Comparison of Analyte Measurements in Capillary Whole Blood and Lithium Heparin Whole Blood Samples With Those in Central Laboratory

Lim

Kim

Koo

et al. 2016

Clinical Laboratory Analysis

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Evaluation of the LABGEO PT10 Point‐Of‐Care Testing Device: Comparison of Analyte Measurements in Capillary Whole Blood and Lithium Heparin Whole Blood Samples With Those in Central Laboratory

Lim

Kim

Koo

et al. 2016

Clinical Laboratory Analysis

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show abstract

“…Using centrifugal and capillary forces, plasma separation, metering, dilution, mixing, and distribution to the cuvettes containing the lyophilised reagents take place in the disc. The Piccolo has been used by the French, British, and US Military in remote locations and has also proved to be an appropriate blood chemistry analyser for biosafety environments, such as those required for monitoring Ebola patients [ 44 ]. Claros Diagnostics (now part of OPKO Health) is another company that has focused its efforts on the development of POC diagnostic devices for developing countries.…”

Section: The Future: Microfluidics As An Emerging Platform For Poimentioning

confidence: 99%

Point-of-Care Diagnostics in Low Resource Settings: Present Status and Future Role of Microfluidics

et al. 2015

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The inability to diagnose numerous diseases rapidly is a significant cause of the disparity of deaths resulting from both communicable and non-communicable diseases in the developing world in comparison to the developed world. Existing diagnostic instrumentation usually requires sophisticated infrastructure, stable electrical power, expensive reagents, long assay times, and highly trained personnel which is not often available in limited resource settings. This review will critically survey and analyse the current lateral flow-based point-of-care (POC) technologies, which have made a major impact on diagnostic testing in developing countries over the last 50 years. The future of POC technologies including the applications of microfluidics, which allows miniaturisation and integration of complex functions that facilitate their usage in limited resource settings, is discussed The advantages offered by such systems, including low cost, ruggedness and the capacity to generate accurate and reliable results rapidly, are well suited to the clinical and social settings of the developing world.

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“…accuracy, precision, specimen stability, consistency etc.) of the Piccolo Xpress analyzer have been investigated in adult and neonatal intensive care unit populations [4] , [5] , [6] , [7] . Our study adds to the literature by providing additional comprehensive evaluation in the pediatric population and interference studies using the Liver Panel Plus discs.…”

Section: Introductionmentioning

confidence: 99%

Assessment of liver function tests on Piccolo Xpress point of care chemistry analyzer in a pediatric hospital

Akbas

González

Edwards

et al. 2015

Practical Laboratory Medicine

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ObjectivesPoint of care testing (POCT) contributes to diagnosis and monitoring with fast testing time and easily performed assays. We evaluated the Abaxis Piccolo Xpress point of care chemistry analyzer using the Liver Panel Plus discs for our pediatric patient population at Texas Children's Hospital.Design and methodsAnalytical performance was evaluated for precision and linearity using quality control materials and commercially available verification samples. Comparison studies were performed between Piccolo Xpress analyzer and Vitros 5600 analyzer using patient samples. Interference studies were carried out using nine different patient pool sera. Lipemia interference was removed using LipoClear for severely lipemic sample pools.ResultsPrecision of all tests was excellent (CVs<5% for all measured analytes except TBIL). All assays were linear and accurate within the allowable total error. Comparison studies showed that three analytes (amylase, GGT and TBIL) had statistically significant bias. Interference study results did not exceed the total allowable error for hemoglobin (<150 mg/dL), bilirubin (<15 mg/dL) and lipemia (<400 mg/dL except ALT, GGT and TP). LipoClear treatment removed lipemia interference for all analytes except total protein.ConclusionsThe Piccolo Xpress chemistry analyzer showed an acceptable analytical performance for precision, linearity and interference from common substances. Increased bias for three analytes in comparison studies could be due to different methodologies.

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Liver function testing on the Abaxis Piccolo Xpress: Use in Ebola virus disease protocols

Cited by 15 publications

References 10 publications

Evaluation of the LABGEO PT10 Point‐Of‐Care Testing Device: Comparison of Analyte Measurements in Capillary Whole Blood and Lithium Heparin Whole Blood Samples With Those in Central Laboratory

Evaluation of the LABGEO PT10 Point‐Of‐Care Testing Device: Comparison of Analyte Measurements in Capillary Whole Blood and Lithium Heparin Whole Blood Samples With Those in Central Laboratory

Point-of-Care Diagnostics in Low Resource Settings: Present Status and Future Role of Microfluidics

Assessment of liver function tests on Piccolo Xpress point of care chemistry analyzer in a pediatric hospital

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