Liver injury during highly pathogenic human coronavirus infections

Xu, Ling; Liu, Jia; Lu, Mengji; Yang, Dongliang; Zheng, Xin

doi:10.1111/liv.14435

Cited by 779 publications

(966 citation statements)

References 49 publications

Supporting

Mentioning

836

Contrasting

Unclassified

Order By: Relevance

“…The present study aimed to analyze SARS-CoV-2-induced ALI, its association with death risk and the prognosis after discharge. The major findings of this study include: (1) ALI is more common in the critically ill COVID-19 patients; (2) Accumulating data demonstrated that SARS-CoV-2 infection caused multiple organ injuries, including myocardial dysfunction, lymphopenia and even acute renal failure [15][16][17]. In the present study, we described ALI among COVID-19 patients.…”

Section: Discussionsupporting

confidence: 49%

Acute liver injury and its association with death risk of patients with COVID-19: a hospital-based prospective case-cohort study

Fei

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Coronavirus disease 2019 (COVID-19) is a newly respiratory infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with multiple organ injuries. The aim of this study was to analyze SARS-CoV-2-induced acute liver injury (ALI), its association with death risk and prognosis after discharge.Methods: Three-hundred and fifty-five COVID-19 patients were recruited. Clinical data were collected from electronic medical records. ALI was evaluated and its prognosis was tracked. The association between ALI and death risk was analyzed.Results: Of 355 COVID-19 patients, 211 were common, 88 severe, and 51 critical ill cases, respectively. On admission, 223 (62.8%) patients were with hypoproteinemia, 151(42.5%) with cholestasis, and 101 (28.5%) with hepatocellular injury. As expected, ALI was more common in critical ill patients. By multivariate logistic regression, male, older age and lymphocyte reduction were three important independent risk factors predicting ALI among COVID-19 patients. Death risk analysis shows that fatality rate was higher among patients with hypoproteinemia than those without hypoproteinemia (RR=9.471, P<0.001). Moreover, fatality rate was higher among patients with cholestasis than those without cholestasis (RR=2.182, P<0.05).

show abstract

Section: Discussionsupporting

confidence: 49%

Acute liver injury and its association with death risk of patients with COVID-19: a hospital-based prospective case-cohort study

Fei

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Previous descriptions of so-called "bystander hepatitis" in the severe acute respiratory syndrome (SARS) coronavirus outbreak of 2002 report viral RNA in the liver parenchyma with histologic findings of hepatocyte apoptosis, mitosis (called out as being particularly prominent), and ballooning. 5,6 The prominent hepatocyte mitosis described in these patients was not observed in our patient, although an occasional mitotic figure could be identified (the significance of this is uncertain in the setting of recent transplantation). The Middle East respiratory syndrome (MERS) coronavirus of 2012 has been associated with elevated liver enzymes with case reports describing peri-venular necrosis and mild portal inflammation.…”

Section: Commentmentioning

confidence: 47%

“…The Middle East respiratory syndrome (MERS) coronavirus of 2012 has been associated with elevated liver enzymes with case reports describing peri-venular necrosis and mild portal inflammation. 6,7 In our case, the most salient finding was an acute hepatitic pattern of injury with prominent clusters of apoptotic hepatocytes. Though this is a non-specific finding, the extent of hepatocyte apoptosis and the large clusters were unusual.…”

Section: Commentmentioning

confidence: 59%

COVID-19–Associated Hepatitis Complicating Recent Living Donor Liver Transplantation

Lagana

Michele

Lee

et al. 2020

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On post-operative day (POD) 4 the patient developed respiratory distress and fever. COVID-19 testing (polymerase chain reaction) was positive. Liver function tests increased approximately 5fold. Liver biopsy showed moderate acute hepatitis with prominent clusters of apoptotic hepatocytes and associated cellular debris. Lobular lymphohistiocytic inflammation was noted.Typical portal features of mild to moderate acute cellular rejection were also noted.Introduction:

show abstract

“…Acute respiratory distress syndrome Eyes 39 Conjunctivitis Liver 40,41 Liver injury Systemic circulation (blood) 3 Thrombosis Kidney 19,18 Renal injury Brain/CNS 1,42 CNS symptoms GI tract 13,12 Diarrhea CNS = central nervous system; GI = gastrointestinal. atrophy, myocardial degenerative changes, and expression of viral nucleocapsid in lungs and intestines.…”

Section: Lungs 38mentioning

confidence: 99%

SARS-CoV-2 Shedding from Asymptomatic Patients: Contribution of Potential Extrapulmonary Tissue Reservoirs

Kalkeri

Goebel

Sharma

2020

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

. The ongoing pandemic COVID-19, caused by SARS-CoV-2, has already resulted in more than 3 million cases and more than 200,000 deaths globally. Significant clinical presentations of COVID-19 include respiratory symptoms and pneumonia. In a minority of patients, extrapulmonary organs (central nervous system, eyes, heart, and gut) are affected, with detection of viral RNA in bodily secretions (stool, tears, and saliva). Infection of such extrapulmonary organs may serve as a reservoir for SARS-CoV-2, representing a potential source of viral shedding after the cessation of respiratory symptoms in recovered patients or in asymptomatic individuals. It is extremely important to understand this phenomenon, as individuals with intermittent virus shedding could be falsely identified as reinfected and may benefit from ongoing antiviral treatment. The potential of SARS-CoV-2 infection to rapidly disseminate and infect extrapulmonary organs is likely mediated through the nonstructural and accessory proteins of SARS-CoV-2, which act as ligands for host cells, and through evasion of host immune responses. The focus of this perspective is the extrapulmonary tissues affected by SARS-CoV-2 and the potential implications of their involvement for disease pathogenesis and the development of medical countermeasures.

show abstract

Liver injury during highly pathogenic human coronavirus infections

Cited by 779 publications

References 49 publications

Acute liver injury and its association with death risk of patients with COVID-19: a hospital-based prospective case-cohort study

Acute liver injury and its association with death risk of patients with COVID-19: a hospital-based prospective case-cohort study

COVID-19–Associated Hepatitis Complicating Recent Living Donor Liver Transplantation

SARS-CoV-2 Shedding from Asymptomatic Patients: Contribution of Potential Extrapulmonary Tissue Reservoirs

Contact Info

Product

Resources

About