Liver Involvement in Hodgkin's Lymphoma: Types of Injuries and Therapeutic Implications

Mihăilă, Romeo-Gabriel

doi:10.18052/www.scipress.com/ijppe.8.1

Cited by 2 publications

(1 citation statement)

References 58 publications

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“…10 The spectrum of liver damage seen in HL includes hepatitis, liver infiltration, biliary obstruction, sepsis, vanishing bile duct syndrome, hemophagocytic lymphohistiocytosis (HLH), posttransplant lymphoproliferative disorders, liver adverse effects of chemotherapy or peliosis hepatis. 12 , 13 Thorough sampling of the postmortem liver specimen revealed large neoplastic cells invading the portal venous radicles, causing periportal multiacinar and bridging confluent hepatic necrosis. In addition, microscopic necrotic foci within the liver parenchyma represented mycobacterial tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

Acute liver failure caused by lymphocyte-depleted Hodgkin lymphoma in tuberculosis and HIV-infected patient

Parkhi,

Premkumar,

Bal

et al. 2024

Autops Case Rep

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The lymphocyte-depleted classic Hodgkin lymphoma (LDCHL), the rarest subtype of classic Hodgkin lymphoma (CHL), is usually diagnosed at an advanced stage (stage IV) and one that unusually involves the liver, causing a rapidly progressive clinical course. We describe a 40-year-old immunocompromised man presenting with a progressive non-cholestatic jaundice and intermittent fever. The abdominal ultrasonography revealed a nodular liver with coarse echotexture and periportal hypodensities. The thoracic and abdominal contrast-enhanced computed tomography revealed right cervical and paraaortic lymphadenopathy, hepatosplenomegaly, diffuse mural thickening of duodenal and jejunal loops, and bilateral lobulated kidneys. Subsequently, he succumbed to his illness secondary to refractory septic shock. On postmortem examination, he was diagnosed with classic Hodgkin lymphoma (lymphocyte-depleted type) involving paraaortic and mediastinal lymph nodes based on morphology and immunochemistry findings. The lymphomatous process involved the liver (causing multiacinar confluent hepatic necrosis) and spleen, both showing tuberculous foci. This autopsy case depicts an uncommon case of acute liver failure due to infiltration of the liver by LDCHL in an HIV-infected patient. The findings of angiotropism and angioinvasion establish the pathological mechanism of liver failure (hepatocellular necrosis) in such cases.

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Section: Discussionmentioning

confidence: 99%

Acute liver failure caused by lymphocyte-depleted Hodgkin lymphoma in tuberculosis and HIV-infected patient

Parkhi,

Premkumar,

Bal

et al. 2024

Autops Case Rep

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Gemcitabine induced cytotoxicity, DNA damage and hepatic injury in laboratory mice

Hailan

Abou-Tarboush

Al-Anazi

et al. 2018

Drug and Chemical Toxicology

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The present study was conducted to demonstrate cytotoxicity, apoptosis and hepatic damage induced by gemcitabine in laboratory mice. Animals were treated with a single dose of gemcitabine (415 mg/kg body wt), equivalent to a human therapeutic dose, and sacrificed after 1, 2 and 3 weeks. A significant decrease in mean body weight and absolute liver weight was registered. The levels of alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were increased as a result of this induced stress. Various structural changes were observed in the liver tissue of treated mice, as evident in the histological sections. Specifically, gemcitabine exposure was able to induce apoptosis in liver cells, and the incidence of TUNEL positive liver cells was increased compared to the control group. DNA fragmentation appeared on agarose gel and flow cytometry analysis confirmed the induction of apoptosis. These findings in gemcitabine-treated animal tissues suggest that inhibition or disruption of cells' DNA synthesis may be the mechanism by which this drug induces toxicity in the animal body.

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Liver Involvement in Hodgkin's Lymphoma: Types of Injuries and Therapeutic Implications

Cited by 2 publications

References 58 publications

Acute liver failure caused by lymphocyte-depleted Hodgkin lymphoma in tuberculosis and HIV-infected patient

Acute liver failure caused by lymphocyte-depleted Hodgkin lymphoma in tuberculosis and HIV-infected patient

Gemcitabine induced cytotoxicity, DNA damage and hepatic injury in laboratory mice

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