Liver Involvement in Infectious Mononucleosis 1

Evans, Alfred S.

doi:10.1172/jci101913

Cited by 45 publications

(10 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results in obstructive jaundice were only slightly below the limits of normal, and suggest that the test is of value in the differential diagnosis of jaundice. The abnormal synthesis in infectious mononucleosis is consistent with evidence that liver damage is frequent in this disease (11,12). Hepatic impairment is also known to occur with chronic ulcerative colitis (13,14), and thyrotoxicosis (15).…”

Section: Discussionsupporting

confidence: 67%

Studies in Para-Aminohippuric Acid Synthesis in the Human: Its Application as a Liver Function Test

Deiss¹,

Cohen²

1950

J. Clin. Invest.

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 67%

Studies in Para-Aminohippuric Acid Synthesis in the Human: Its Application as a Liver Function Test

Deiss¹,

Cohen²

1950

J. Clin. Invest.

View full text Add to dashboard Cite

“…The concomitance, however, of occasional hyperbilirubinemia, frequent elevation of alkaline phosphatase activity (2,5,6), and histopathologic evidence of liver involvement (1,(8)(9)(10)(11)(12)(13)(14) makes plausible the association of disturbed hejatic function and the alterations of the serum proteins. Such a conception is not in any sense incompatible with the probable extra-hepatic origin of serum globulins.…”

Section: Discussionmentioning

confidence: 99%

The Serum Proteins in Infectious Mononucleosis. Electrophoretic Studies

Sterling¹

1949

J. Clin. Invest.

View full text Add to dashboard Cite

Previous investigations have shown the very frequent occurrence in infectious mononucleosis of abnormal findings on liver function tests (1-7), and of hepatic involvement on histologic examination of both autopsy (8-11) and biopsy material (1, 12-14) in cases with and without jaundice.Alterations observed in the composition of the serum proteins (2, 4, 6, 15, 16a) appear to be compatible with the occurrence of positive cephalin-cholesterol flocculation and thymol turbidity

show abstract

“…The treatment for IM is generally supportive and only alleviates symptoms, as EBV cannot be cured; these treatments include glucose and sodium chloride intravenous infusion, reduced glutathione intravenous infusion, pantoprazole sodium injection, and oral loxoprofen and bicyclol tablets intake ( 1 , 2 ). Abnormality of hepatic function is commonly encountered in IM; however, it has been demonstrated for many years that increases in alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyl transferase (GGT) occur more frequently in IM than bilirubin abnormalities ( 1 – 12 ). However, the underlying reasons for these elevations remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Infectious mononucleosis and hepatic function

et al. 2018

View full text Add to dashboard Cite

Abnormal hepatic function is common in infectious mononucleosis (IM). However, it remains unknown why increased transferase levels are more common than bilirubin abnormalities in IM. The current study aimed to investigate these associations in the Chinese population. A total of 95 patients with IM (47 males and 48 females) were enrolled in the current study, as well as 95 healthy controls. Patients were sorted by sex. A receiver operating characteristic (ROC) curve was used to determine cut-off values for IM diagnosis and prediction. Crude and adjusted odds ratios (OR) for IM were analyzed using binary logistic regression. It was determined that alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyl transferase (GGT) levels were significantly higher in patients with IM compared with controls; however, total bilirubin (TB) levels were significantly lower in patients with IM. ROCs demonstrated that, if ALT, AST and GGT concentrations were higher than, or if TB was lower than, cut-off values, they were predictive of IM. Binary logistic regression identified that the risk of IM in patients exhibiting high levels of transferases was significantly increased, particularly in males. Crude ORs in ALT quartile 4 were 21.667 and 10.111 for males and females, respectively and adjusted ORs were 38.054 and 9.882, respectively. A significant IM risk of IM was evident in patients with low bilirubin levels and females appeared to be particularly susceptible. For example, crude ORs in quartile 1 were 8.229 and 8.257 for males and females, respectively and adjusted ORs were 8.883 and 10.048, respectively. Therefore, the current study identified a positive association between transferase levels and IM and a negative association between TB and IM. Therefore, the results of the current study indicate that high transferases are suggestive of IM, particularly in males, whereas low TB is suggestive for IM, particularly in females.

show abstract

Liver Involvement in Infectious Mononucleosis 1

Cited by 45 publications

References 8 publications

Studies in Para-Aminohippuric Acid Synthesis in the Human: Its Application as a Liver Function Test

Studies in Para-Aminohippuric Acid Synthesis in the Human: Its Application as a Liver Function Test

The Serum Proteins in Infectious Mononucleosis. Electrophoretic Studies

Infectious mononucleosis and hepatic function

Contact Info

Product

Resources

About