Liver lipid metabolism

Nguyen, Patrick; Leray, Véronique; Diez, Marianne; Serisier, Samuel; Bloch, J; Siliart, Brigitte; Dumon, H.

doi:10.1111/j.1439-0396.2007.00752.x

Cited by 772 publications

(540 citation statements)

References 61 publications

Supporting

Mentioning

522

Contrasting

Unclassified

Order By: Relevance

“…MTTP knockout mice caused a striking reduction in VLDL assembly and secretion in the liver (Liao et al, 2003). ApoB is a key component whose synthesis rate controls the overall rate of VLDL production (Nguyen et al, 2008). FoxO1 is a transcription factor that plays a key role in the hepatic VLDL assembly and secretion.…”

Section: Discussionmentioning

confidence: 99%

Effects of inhibiting PI3K-Akt-mTOR pathway on lipid metabolism homeostasis in goose primary hepatocytes

Liu

Han

Wan

et al. 2016

Animal

View full text Add to dashboard Cite

Phosphatidylinositol-3 kinases (PI3K)-Protein kinase B (Akt)-mammalian target of rapamycin (mTOR) pathway plays an important role in the synthesis and secretion of triacylglycerol. However, the mechanism of PI3K-Akt-mTOR pathway in regulating lipid metabolism of goose liver was poorly understood. The purpose of this study was to determine how PI3K-Akt-mTOR pathway regulating lipid metabolic homeostasis in goose hepatocytes. Goose primary hepatocytes were treated with different PI3K-Akt-mTOR signal inhibitors (LY294002, rapamycin and NVP-BEZ235) for 24 h. The results showed that these inhibitors evidently inhibited PI3K-Akt-mTOR downstream signaling. Meanwhile, these PI3K-Akt-mTOR inhibitors reduced intracellular lipid accumulation, decreased the mRNA expression and protein content of genes involved in the de novo fatty acid synthesis, while increased the transcriptional and protein level of key factors involved in fatty acid oxidation and very low density lipoprotein (VLDL) assembly and secretion. Conclusion: These findings suggested that the reduction of lipids accumulation induced-by inhibiting PI3K-Akt-mTOR pathway was closely linked to the decrease of lipogenesis, the increase of fatty acids oxidation, and the increase of VLDL assembly and secretion in goose hepatocytes.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of inhibiting PI3K-Akt-mTOR pathway on lipid metabolism homeostasis in goose primary hepatocytes

Liu

Han

Wan

et al. 2016

Animal

View full text Add to dashboard Cite

show abstract

“…In poultry, however, the liver rather than adipose tissue, plays a key role in lipid metabo- lism. Fatty acid synthesis in poultry also mainly occurs in the liver rather than in fat tissue (Nguyen et al, 2008). Therefore, the liver is a vital organ for studying the effect of cold stress on the body in poultry.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling of Broiler Liver under Cold Stress by High-Throughput Sequencing Technology

Liu

Lü

et al. 2017

J. Poult. Sci.

View full text Add to dashboard Cite

Cold stress is a major environmental factor restricting the sustainable development of animal husbandry. To gain insight into the gene-regulation processes in broilers under cold stress, gene expression profiling was conducted using high-throughput Solexa sequencing of broiler liver tissue under cold stress conditions and control conditions. According to Solexa sequencing, we identified 255 genes whose expression levels differed between the treatment and control group. Under cold stress, 135 genes were up-regulated and 120 genes were down-regulated genes compared with levels in the control group. Moreover, 469 genes were expressed only in the control group, and 172 genes were expressed only in the treatment group. These data were confirmed by real-time quantitative PCR. Gene Ontology enrichment analysis showed that the differentially expressed genes (DEGs) were mainly enriched in material metabolism and immune functions. KEGG enrichment analysis showed that DEGs were enriched in pyruvate metabolism, glycolysis/gluconeogenesis, fatty acid metabolism，insulin signaling pathway and others. In conclusion, these results may serve as an important reference for broiler breeding and provide new clues for the elucidation of molecular mechanisms of cold stress.

show abstract

“…Once inside the liver, the fatty acids derived from the TG may be used to obtain energy or for the synthesis of complex lipids such as phospholipids. Alternatively, however, they may be re-synthesized into TG, packaged together with cholesterol and phospholipid into very low density lipoprotein (VLDL) and returned to the blood [9]. Since hepatic VLDL secretion is increased postprandially [10], postprandial lipemia is caused by raised levels of CM, CMR and VLDL in the blood.…”

Section: Postprandial Hyperlipidemia As a Risk Factor For Atherosclermentioning

confidence: 99%

Postprandial Lipid Metabolism: The Missing Link Between Life-Style Habits and the Increasing Incidence of Metabolic Diseases in Western Countries?~!2009-09-30~!2010-01-26~!2010-03-30~!

Bravo¹,

Napolitano²,

Botham³

2010

TOTRANSMJ

View full text Add to dashboard Cite

Postprandial lipemia is the transient increase in blood lipids which occurs after a meal containing fat and is caused by raised levels of triglyceride-rich lipoproteins (TRLs) in the blood. Delayed clearance of TRLs leads to postprandial hyperlipidemia, and there is now a great deal of evidence to support the idea that this condition is an important risk factor for cardiovascular disease (CVD). Western lifestyle habits including: diets low in fresh fruit and vegetables and high in fat and processed food, alcohol consumption, smoking, and lack of exercise tend to promote postprandial hyperlipidemia, and it is a characteristic feature of increasingly common metabolic diseases such as obesity, insulin resistance and type 2 diabetes which are also linked to modern lifestyle behaviour and which carry an increased risk of CVD development. Modification of lifestyle factors such as changing to a healthier diet, weight loss, reducing alcohol consumption and increasing exercise can cause significant reductions in postprandial hyperlipidemia and thus help to reduce this risk. Despite the growing recognition that the extent of postprandial lipemia is a good predictor of CVD, no standardized methodology for its measurement is currently available. Determination of blood TG levels after consumption of a standard test meal is likely to be the most convenient approach for a routine clinical test, and we propose a standard test meal which is easily adaptable for the variations in dietary habits in different countries. Greater use of postprandial lipid determination will aid in the translation of our extensive knowledge on the role of nutrition in health into national and international policy.

show abstract

Liver lipid metabolism

Cited by 772 publications

References 61 publications

Effects of inhibiting PI3K-Akt-mTOR pathway on lipid metabolism homeostasis in goose primary hepatocytes

Effects of inhibiting PI3K-Akt-mTOR pathway on lipid metabolism homeostasis in goose primary hepatocytes

Gene Expression Profiling of Broiler Liver under Cold Stress by High-Throughput Sequencing Technology

Postprandial Lipid Metabolism: The Missing Link Between Life-Style Habits and the Increasing Incidence of Metabolic Diseases in Western Countries?~!2009-09-30~!2010-01-26~!2010-03-30~!

Contact Info

Product

Resources

About