Liver Match, a prospective observational cohort study on liver transplantation in Italy: Study design and current practice of donor–recipient matching

Angélico, M.; Cillo, Umberto; Fagiuoli, Stefano; Gasbarrini, Antonio; Gavrila, C.; Marianelli, T.; Costa, Alessandro Nanni; Nardi, Alessandra; Strazzabosco, Mario; Burra, Patrizia; Agnes, Salvatore; Baccarani, Umberto; Calise, Fulvio; Colledan, M.; Cuomo, O.; Carlis, Luciano De; Donataccio, M.; Ettorre, Giuseppe Maria; Gerunda, G.E.; Gridelli, Bruno; Lupo, L.; Mazzaferro, Vincenzo; Pinna, Antonio D.; Risaliti, Andrea; Salizzoni, Mauro; Tisone, Giuseppe; Valente, Umberto; Rossi, Giorgio; Rossi, Massimo; Zamboni, Fausto

doi:10.1016/j.dld.2010.11.002

Cited by 70 publications

(73 citation statements)

References 29 publications

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“…We acknowledge that our study, mainly focusing on anti-HBc-positive donors, was downsized for the recognition of seronegative OBI. However, since the prevalence of anti-HBc-positivity is higher in elderly donors [20,21], we matched for age the anti-HBc-negative group with the anti-HBc-positive one in order to balance baseline conditions. Despite this, we encountered no OBI case in anti-HBc-negative donors, supporting the concept that the occurrence of seronegative OBI might be a rare occurrence in the setting of LT.…”

Section: Discussionmentioning

confidence: 99%

Prediction of occult hepatitis B virus infection in liver transplant donors through hepatitis B virus blood markers

Tandoi

Caviglia

Pittaluga

et al. 2014

Digestive and Liver Disease

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Section: Discussionmentioning

confidence: 99%

Prediction of occult hepatitis B virus infection in liver transplant donors through hepatitis B virus blood markers

Tandoi

Caviglia

Pittaluga

et al. 2014

Digestive and Liver Disease

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“…MELD scores also cannot gauge the severity of several diseases currently considered ''MELD exceptions,'' or of hepatocellular carcinoma (HCC) in patients with compensated cirrhosis (2). In a recent prospective Italian series of LT, MELD was unable to describe the disease's severity in almost 50% of the cases (3).…”

Section: Introductionmentioning

confidence: 99%

A Multistep, Consensus-Based Approach to Organ Allocation in Liver Transplantation: Toward a “Blended Principle Model”

Cillo

Burra

Mazzaferro

et al. 2015

American Journal of Transplantation

184

129

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“…The acceptance of elderly donors allowed significantly broadening the donor pool, and in our country, in the last decade, the incidence of ideal donors has been significantly decreasing [33][34][35]. In this series, median donor age was 54 years, and 9% of grafts were procured from donors over 75; ideal donor whole grafts were used only in 15% of the procedures, whereas one or multiple risk factors for PDF were present in 85% of the donors, including partial grafts.…”

Section: Discussionmentioning

confidence: 96%

“…The new idea, according to which the sickest patient may benefit from any organ, is based on the finding that there is no significant interaction between donor risk index and MELD score in the recipient [13]. However, ECD grafts should be viewed as a spectrum that can be scored and matched to an appropriate recipient for optimal utilization at a time of scarcity [12,26,30,[32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Results of a newborn liver transplant program in the era of piggyback technique and extended donor criteria in Italy

et al. 2011

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The aim of this study was to critically analyze the early and long-term results of a newborn liver transplantation (LTx) centre using piggyback technique (PT) without venovenous bypass and portocaval shunt in the era of extended criteria donors (ECDs). Between 2002 and 2010, a total of 229 LTx were performed in 225 patients, with the shortest as possible cold ischemia time (CIT) policy. The charts of the donors and recipients and the intraoperative data were retrospectively reviewed in order to define the feasibility of PT and surgical outcome, and long-term graft and patient survival. PT feasibility rate was 100%, with a median duration of surgery of 390 min (range 210-630) and median unit of packed RBC transfused intraoperatively of 1 U (range 1-10). Median CIT was 400 min (range 130-870), and median AST peak was 403 mmol/L (range 48-16,900). ECDs graft rate was 85%. Over all primary dysfunction and non-function (PNF) rates were 7.4 and 2.2%, respectively and increased with graft steatosis >30% (P < 0.004). Mortality, morbidity, re-operation and re-LTx rates were 4.4, 25, 6.1 and 1.3%, respectively, and median hospital stay was 18 days (range 8-150). On the long term, graft and patient 5-year overall survival were 72 and 74%, respectively, and re-LTx rate was 0.4%. Survival was significantly affected by recipient HCV-Ab seropositive status (67 vs. 85%, P = 0.023). Liver transplantation can be performed with low morbidity and mortality rates, despite ECDs. PT is a safe and effective procedure that, combined with short CIT, entailed prompt early functional recovery of the grafts and positive long-term results.

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Liver Match, a prospective observational cohort study on liver transplantation in Italy: Study design and current practice of donor–recipient matching

Cited by 70 publications

References 29 publications

Prediction of occult hepatitis B virus infection in liver transplant donors through hepatitis B virus blood markers

Prediction of occult hepatitis B virus infection in liver transplant donors through hepatitis B virus blood markers

A Multistep, Consensus-Based Approach to Organ Allocation in Liver Transplantation: Toward a “Blended Principle Model”

Results of a newborn liver transplant program in the era of piggyback technique and extended donor criteria in Italy

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