Liver Metastasis of Thymoma: Case Report and Review of the Literature

Mallick, Jayati; Peterson, Joshua; Piña‐Oviedo, Sergio; Patel, Nekita; Venkatesan, Rohit; Stevenson, Heather L.; Qiu, Suimin; Shen, Yuan; Lyapichev, Kirill A.

doi:10.1177/10668969221115818

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…The thymus, a solid organ situated in the anterior superior mediastinum, contains both lymphoid and epithelial components (1,2). Thymomas, originating from epithelial cells of the thymus, exhibit relatively slow growth and typically spread directly, with an extremely rare incidence of distant dissemination to extrathoracic organs, though the exact frequency remains uncertain (2).…”

Section: Introductionmentioning

confidence: 99%

“…The 2021 "World Health Organization (WHO) Classification of Thoracic Tumours" primarily categorizes thymomas, epithelial tumors of the thymus, based on cytomorphology. Benign cytomorphology types include A, AB, B1, B2, and B3, while malignant types correspond to thymic carcinoma, formerly categorized as type C (1,5). Metastases are predominantly found in the pleural space, lung parenchyma, or bones, and are more commonly observed in patients previously treated for the primary tumor (6,7).…”

Section: Introductionmentioning

confidence: 99%

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Hepatic metastasis of thymoma: Case Report of a fast-growing abdominal mass in a pregnant patient

Raspopović,

Micić,

Perišić

et al. 2023

Sanamed

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Introduction: Thymomas are the most common primary mediastinal tumors originating from epithelial cells of the thymus, demonstrating epithelial differentiation. Pathologically, thymomas exhibit relatively slow growth and typically spread directly, with extremely rare occurrences of distant dissemination to extrathoracic organs. The precise incidence of such dissemination remains unknown. Distant metastases, particularly to the liver, are exceptionally rare, with only a few cases documented in the literature. Case Report: A 39-year-old woman, in her 31st week of gestation, presented with abdominal pain and discomfort. She underwent ultrasonography, followed by an urgent MRI of the abdomen due to a protruding tumor mass in the liver. Shortly after delivering a healthy baby via cesarean section, she was admitted to the hospital for a CT scan of the abdomen. The imaging revealed multiple focal changes in the liver parenchyma, exhibiting radiological characteristics consistent with focal nodular hyperplasia. Less likely differential diagnoses included adenomas or hemangiomas. Subsequently, she underwent staged hepatectomy, and the results of the pathological analysis confirmed the presence of type B thymoma metastases in the liver. Conclusion: According to the available data in the literature, metastatic thymomas are often identified in patients who have previously undergone treatment for the primary disease. Our patient did not have a history of thymectomy, as confirmed by postoperative chest scans. Onset of symptoms during late pregnancy guided our diagnosis, relying on overall clinical and radiological findings of the detected tumor. Our treatment involved staged hepatectomy post-childbirth, followed by adjuvant chemotherapy. Further comprehensive studies are essential to precisely understand neoplasm behaviors like thymoma for timely detection and effective treatment.

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Section: Introductionmentioning

confidence: 99%