Liver morphology and function in visceral leishmaniasis (Kala-azar).

Hag, I. A. El; Hashim, F. A.; Toum, Isam A. El; Homeida, M; Kalifa, M el; Hassan, A.M. El

doi:10.1136/jcp.47.6.547

Cited by 97 publications

(64 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This lesion also was noted in HVL and experimental models of the disease (Gonzalez et al, 1988;El Hag et al, 1994 (Willians and Willians, 1983;Scheffield, 1990;Murray and Nathan, 1999). According to Murray (2001), an immunologically active (epithelioid-type) granuloma is required for functional antimicrobial action.…”

Section: Discussionmentioning

confidence: 99%

Hepatic granulomas in canine visceral leishmaniasis and clinical status

Sant'Ana¹,

Lima²,

Oliveira

et al. 2007

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

The histopathological description of intralobular hepatic granulomas in animals with a defined clinical status (asymptomatic, oligosymptomatic and symptomatic animals) was reported. Seventy-one mongrel dogs naturally infected with Leishmania chagasi were obtained from two Brazilian endemic areas: João Pessoa, PB and Belo Horizonte, MG. The hepatic parasite load was determined and compared to granuloma formation. Liver fragments from all infected animals showed remarkable leishmaniotic granulomatous inflammatory reaction. Granulomas with variable size were constituted by macrophages (parasitized or not with amastigotes of L. chagasi), some epithelioid cells, small numbers of lymphocytes, plasma cells, and rare neutrophils. Asymptomatic dogs had higher numbers of granulomas than oligosymptomatic and symptomatic animals from both geographical regions. However, the average diametric size of granulomas was very heterogeneous in all groups, independently of the geographic region (P>0.05). Parasite tissue load did not show any difference among liver fragments of all animals, especially when considering the defined clinical status and/or their geographic origin.

show abstract

Section: Discussionmentioning

confidence: 99%

Hepatic granulomas in canine visceral leishmaniasis and clinical status

Sant'Ana¹,

Lima²,

Oliveira

et al. 2007

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

show abstract

“…There may be centrilobular hepatocellular necrosis (common in young children), fatty infiltration and fibrin ring granuloma formation. In late stages, the liver becomes increasingly fibrotic, giving the appearance of nodular cirrhosis 14 . Biochemical liver dysfunction is common in kala-azar.…”

Section: Discussionmentioning

confidence: 99%

Portal hypertension and reactive hemophagocytosis in pediatric visceral leishmaniasis

Das

Sarkar

Chatterjee

et al. 2015

Bangladesh J Med Sci

View full text Add to dashboard Cite

Abstract:A 10 year old boy suffering from prolonged low grade fever, progressive pallor, one episode of haematemesis and melaena, was found to have hepatosplenomegaly, features of portal hypertension on abdominal ultrasound, and grade II varices in upper gastrointestinal endoscopy. During hospital stay for diagnostic workup, he developed features of hepatic failure and pancytopenia. Bone marrow aspirate revealed hemophagocytosis and plenty of Leishman-Donovan bodies. The child received Injection Sodium Stibogluconate to treat leishmaniasis and received supportive therapy for hepatic failure and pancytopenia. The child responded well to treatment.

show abstract

“…The liver involvement in visceral leishmaniasis may appear as chronic granulomatous hepatitis [5]. Fulminant hepatitis has been described in 3 of 150 immunocompetent children with Kala-azar in an Indian study [6].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis with Fibrin-Ring Granulomas

Khanlari

Bodmer²,

Terracciano

et al. 2007

Infection

View full text Add to dashboard Cite

We describe a 66-year-old woman hospitalized with fever, fatigue and hepatopathy. In her medical history arterial hypertension (treated with propranolol and lisinopril), diabetes mellitus type 2 (no treatment before admission) and a gout arthropathy were noted wherefore a therapy with allopurinol 300 mg per day has been started 4 months before. Liver biopsy revealed fibrin-ring granulomas, compatible with allopurinolinduced hepatitis. Because of persistence of high fever after stopping allopurinol, steroids (1 mg/kg) were started. Under this treatment, she developed pancytopenia and fever. The bone marrow aspiration revealed Leishmania infantum. A second liver biopsy showed amastigotes and a disappearance of the granulomas. The history revealed a travel to Malta 2 years earlier. Despite adequate treatment with liposomal amphotericin B the patient deteriorated and finally died in septic shock.

show abstract

Liver morphology and function in visceral leishmaniasis (Kala-azar).

Cited by 97 publications

References 11 publications

Hepatic granulomas in canine visceral leishmaniasis and clinical status

Hepatic granulomas in canine visceral leishmaniasis and clinical status

Portal hypertension and reactive hemophagocytosis in pediatric visceral leishmaniasis

Hepatitis with Fibrin-Ring Granulomas

Contact Info

Product

Resources

About