Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits

Septiana, Wahyunia Likhayati; Ayudyasari, Wulan; Gunardi, Hardian; Pawitan, Jeanne Adiwinata; Balachander, Gowri Manohari; Yu, Hanry; Antarianto, Radiana Dhewayani

doi:10.1007/s11626-023-00817-8

In Vitro Cell.Dev.Biol.-Animal

2023

DOI: 10.1007/s11626-023-00817-8

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Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits

Wahyunia Likhayati Septiana,

Wulan Ayudyasari,

Hardian Gunardi

et al.

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2024

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Cited by 3 publications

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Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities

Hussein,

Ahmadzada,

Correa

et al. 2024

Bioactive Materials

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Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities

Hussein,

Ahmadzada,

Correa

et al. 2024

Bioactive Materials

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Hydrogel-Based Strategies for Liver Tissue Engineering

Zhang,

Li,

Dong

et al. 2024

Chem Bio Eng.

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The liver's role in metabolism, detoxification, and immune regulation underscores the urgency of addressing liver diseases, which claim millions of lives annually. Due to donor shortages in liver transplantation, liver tissue engineering (LTE) offers a promising alternative. Hydrogels, with their biocompatibility and ability to mimic the liver's extracellular matrix (ECM), support cell survival and function in LTE. This review analyzes recent advances in hydrogel-based strategies for LTE, including decellularized liver tissue hydrogels, natural polymer-based hydrogels, and synthetic polymer-based hydrogels. These materials are ideal for in vitro cell culture and obtaining functional hepatocytes. Hydrogels' tunable properties facilitate creating artificial liver models, such as organoids, 3D bioprinting, and liveron-a-chip technologies. These developments demonstrate hydrogels' versatility in advancing LTE's applications, including hepatotoxicity testing, liver tissue regeneration, and treating acute liver failure. This review highlights the transformative potential of hydrogels in LTE and their implications for future research and clinical practice.

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Decellularized extracellular matrix for organoid and engineered organ culture

Guo,

Liu,

Zhang

et al. 2024

J Tissue Eng

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The repair and regeneration of tissues and organs using engineered biomaterials has attracted great interest in tissue engineering and regenerative medicine. Recent advances in organoids and engineered organs technologies have enabled scientists to generate 3D tissue that recapitulate the structural and functional characteristics of native organs, opening up new avenues in regenerative medicine. The matrix is one of the most important aspects for improving organoids and engineered organs construction. However, the clinical application of these techniques remained a big challenge because current commercial matrix does not represent the complexity of native microenvironment, thereby limiting the optimal regenerative capacity. Decellularized extracellular matrix (dECM) is expected to maintain key native matrix biomolecules and is believed to hold enormous potential for regenerative medicine applications. Thus, it is worth investigating whether the dECM can be used as matrix for improving organoid and engineered organs construction. In this review, the characteristics of dECM and its preparation method were summarized. In addition, the present review highlights the applications of dECM in the fabrication of organoids and engineered organs.

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Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits

Cited by 3 publications

References 71 publications

Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities

Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities

Hydrogel-Based Strategies for Liver Tissue Engineering

Decellularized extracellular matrix for organoid and engineered organ culture

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