Liver protective activity of a hydroethanolic extract ofArrabidaea chica(Humb. and Bonpl.) B. Verl. (pariri)

Abstract

Background:Folk medicine uses preparations of Arrabidaea chica (pariri) leaves to treat various liver pathologies. We evaluated the effects of the hydroethanolic extract of these leaves (CHEE) on an in vivo model of liver intoxication.Materials and Methods:Different groups of rats were treated orally for 7 days with CHEE at doses of 300, 500 or 600 mg/kg or silymarin at 35 mg/kg. The control group received only 0.5 ml of distilled water. After 7 days of treatment, both the groups received CCl4, and activities of glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT) and bilirubin level were assessed. The ability of CHEE to suppress hepatic injury triggered by CCl4 was evaluated based on suppression (%) of activities of GOT, GPT and bilirubin levels.Results:The chromatograms of the CHEE obtained at 330 and 400 nm show features of two main classes of secondary metabolites: quinones and flavonoids. The administration of 300, 500 or 600 mg/kg of CHEE resulted in the reduction of GPT levels by 85.34%, 88.59% and 93.72%, respectively. The suppression of GOT levels was 56.86%, 65.27% and 68.95%, respectively, and that of plasma bilirubin was 83.81%, 83.12% and 84.14%, respectively. These results demonstrate the protective character of CHEE and its ability to maintain the functional integrity of hepatic cells.Conclusions:The results obtained are possibly due to the presence of quinones and flavonoids in A. chica CHEE, both detected using high performance liquid chromatography.

Arrabidaea chicaHexanic Extract Induces Mitochondrion Damage and Peptidase Inhibition onLeishmaniaspp.

“…In vivo assays demonstrated an impressive reduction of lesion size of about 96% [ 28 ]. In addition, Lima de Medeiros et al reported the hepatoprotective activity of the hydroethanolic extract of A. chica based on the suppression of hepatic markers such as serum glutamic oxaloacetate transaminase (GOT) and glutamic pyruvate transaminase (GPT) and decreasing levels of plasma bilirubin [ 29 ]. Considering the clinical manifestations related to cutaneous and visceral leishmaniasis, such as skin lesions and hepatic damage, respectively, A. chica could represent a promising phytotherapeutic agent.…”

Attenuation of CCl4-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats

“…The liver is one of the largest and highly complex organs with multifunction, including nutrient storage, maintenance of homeostasis, secretory and excretory function, and synthesis of proteins [31]. These functions also include the metabolism of certain hormones, lipid metabolism (cholesterol, triglycerides, and high-density lipoproteins (HDL)), protein metabolism, and detoxification of xenobiotics [32]. The model used in the present study has been subjected to thorough critical appraisal and validated animal models of hepatorenal protective activity of honey in rats against CCl 4 as a hepatorenal toxin to prove its claims in folklore practice against liver and kidney disorders.…”

Hepatoprotective activity of Ficus religiosa leaves against isoniazid+rifampicin and paracetamol induced hepatotoxicity

“…[34] Number of medicinal plants has been reported with good hepatoprotective activity with potential antioxidative mechanism due to presence of flavonoids and phenolic compounds. [353637] The protective role of this plant against liver toxicity might be through antioxidative effect of flavonoids rich in the plant.…”