Liver Regeneration after Liver Transplantation

Taki-Eldin, Ahmed; Zhou, Lin; Xie, Haiyang; Zheng, Shusen

doi:10.1159/000337865

Cited by 48 publications

(50 citation statements)

References 236 publications

(156 reference statements)

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“…A close relationship between cytokines and HCC has been reported in recent years [28][29][30][31]. IL6 is a crucial effector cytokine that is involved in hepatic physiology, including hepatoprotection, the acute-phase response, and mitogenesis in liver regeneration [11,32]. This effect of IL6 is achieved through the STAT3 and MAPK signaling pathways by the binding of IL6 to its receptor complex (gp130-IL6R) on hepatocytes [11].…”

Section: Discussionmentioning

confidence: 92%

Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

et al. 2016

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Section: Discussionmentioning

confidence: 92%

Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

et al. 2016

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“…Rat P-OLT is a complex microsurgical model which is appropriate for answering a great number of scientific questions concerning the following topics: liver regeneration [5,6], small-for-size syndrome [7], rejection and tolerance [8], and graft ischemia-reperfusion injury [9], among others. Despite its feasibility, the literature is confusing regarding the technical aspects of rat P-OLT, and most of the research groups use their well-tried ‘in-house' protocols, which makes a comparison of their findings difficult.…”

Section: Introductionmentioning

confidence: 99%

Improving Research Practice in Rat Orthotopic and Partial Orthotopic Liver Transplantation: A Review, Recommendation, and Publication Guide

Czigány

Iwasaki²,

Yagi³

et al. 2015

Eur Surg Res

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Background: Due to a worldwide shortage of donor organs for liver transplantation, alternative approaches, such as split and living donor liver transplantations, were introduced to increase the donor pool and reduce mortality on liver transplant waiting lists. Numerous details concerning the mechanisms and pathophysiology of liver regeneration, small-for-size syndrome, rejection, and tolerance in partial liver transplantation facilitated the development of various animal models. The high number of preclinical animal studies contributed enormously to our understanding of many clinical aspects of living donor and partial liver transplantations. Summary: Microsurgical rat models of partial orthotopic liver transplantation are well established and widely used. Nevertheless, several issues regarding this procedure are controversial, not clarified, or not yet properly standardized (graft rearterialization, size reduction techniques, etc.). The major aim of this literature review is to give the reader a current overview of rat orthotopic liver transplantation models with a special focus on partial liver transplantation. The aspects of model evolution, microsurgical training, and different technical problems are analyzed and discussed in detail. Our further aim in this paper is to elaborate a detailed publication guide in order to improve the quality of reporting in the field of rat liver transplantation according to the ARRIVE guidelines and the 3R principle. Key Messages: Partial orthotopic liver transplantation in rats is an indispensable, reliable, and cost-efficient model for transplantation research. A certain consensus on different technical issues and a significant improvement in scientific reporting are essential to improve transparency and comparability in this field as well as to foster refinement.

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“…It has opened an exciting opportunity to study liver regeneration in humans [11]. But liver transplant patients with severe illness, surgery complicated condition changes quickly.…”

Section: Discussionmentioning

confidence: 99%

16 cases of clinical treating experience after liver transplantation

He¹,

Xia²,

Wang³

et al. 2017

Transplant Open

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Objective: To discuss clinical nursing experiences after liver transplantation retrospectively. Methods From 2003 to 2013 in our hospital, a total of 16 patients with liver transplant, whose clinical nursing of patients experience would be summarized, and the important and difficult points in the process of it would be sum up.Results: Out of 16 cases of liver transplantation one of them died soon due to intolerance for surgery, and two patients died postoperative due to respiratory system function failure. Other patients recovered well and discharged were from hospital. The percentage of living cases after one year of operation was up to 81.3%. Conclusion:The clinical nursing process after liver transplant is complex, and the technical operation is difficult, therefore it requires nurses in nursing processes to have comprehensive grasp and have skilled operation in order to improve the survival rate of patients and quality of life after liver transplantation.

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Liver Regeneration after Liver Transplantation

Cited by 48 publications

References 236 publications

Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

Donor interleukin 6 gene polymorphisms predict the recurrence of hepatocellular carcinoma after liver transplantation

Improving Research Practice in Rat Orthotopic and Partial Orthotopic Liver Transplantation: A Review, Recommendation, and Publication Guide

16 cases of clinical treating experience after liver transplantation

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