Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study

Laconi, Sergio; Curreli, Francesca; Diana, Silvana; Pasciu, Daniela; Filippo, Greta De; Sarma, D.S.R.; Pani, P.; Laconi, Ezio

doi:10.1016/s0168-8278(99)80320-1

Cited by 79 publications

(85 citation statements)

References 12 publications

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“…Under normal conditions, mitotic cells and expression of proliferating nuclear antigen are elevated on days 1 and 2 after hepatectomy (30,31). At day 2 the hepatectomy Marimastat™ mice demonstrated a statistically significant lower MI and PCNA index, indicating inhibition of regeneration.…”

Section: Discussionmentioning

confidence: 96%

A Critical Role for Matrix Metalloproteinases in Liver Regeneration

Alwayn

Verbesey

Kim

et al. 2008

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 96%

A Critical Role for Matrix Metalloproteinases in Liver Regeneration

Alwayn

Verbesey

Kim

et al. 2008

Journal of Surgical Research

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“…These include partial hepatectomy, administration of toxic compounds, or a combination of both, and transgenic expression of certain proteins. 1,2 In contrast to in vitro experiments, these approaches raise fewer questions concerning the influence of artificial matrices on the function and behavior of hepatocytes and other liver cell types.Although these procedures have generated useful information on rodent liver regeneration, stem cell activation, and other processes, extrapolating these findings to the Abbreviations: uPA, urokinase plasminogen activator; HBV, hepatitis B virus; HCV, hepatitis C virus; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; PAS, periodic-acid-Schiff. From the…”

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confidence: 99%

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confidence: 99%

Morphological and biochemical characterization of a human liver in a uPA‐SCID mouse chimera†‡

et al. 2005

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D espite decades of research, the processes that govern liver development and regeneration are only partially understood. A good understanding of the mechanisms that play a role in these processes is important because it may lead to new treatments of human liver diseases. Several in vivo experimental conditions have been used to study liver regeneration and repair and the interaction of different cell types in these processes. These include partial hepatectomy, administration of toxic compounds, or a combination of both, and transgenic expression of certain proteins. 1,2 In contrast to in vitro experiments, these approaches raise fewer questions concerning the influence of artificial matrices on the function and behavior of hepatocytes and other liver cell types.Although these procedures have generated useful information on rodent liver regeneration, stem cell activation, and other processes, extrapolating these findings to the Abbreviations: uPA, urokinase plasminogen activator; HBV, hepatitis B virus; HCV, hepatitis C virus; HBsAg, hepatitis B surface antigen; HBeAg, hepatitis B e antigen; PAS, periodic-acid-Schiff. From the

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“…The model described by the authors is based on the use of retrorsine, a pyrrolizidine alkaloid that exerts a long-lasting block on hepatocyte cell cycle. 26,27 When rats exposed to retrorsine undergo 2/3 partial hepatectomy (PH), clusters of small hepatocytes rapidly emerge among surrounding megalocytic cells. These cells are still actively proliferating at 2 weeks after PH, and by 1 month they occupy the bulk of the liver and have virtually completed the regeneration process, apparently replacing the original parenchymal cells.…”

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confidence: 99%