2022
DOI: 10.3389/fonc.2022.991944
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Liver resection, radiofrequency ablation, and radiofrequency ablation combined with transcatheter arterial chemoembolization for very-early- and early-stage hepatocellular carcinoma: A systematic review and Bayesian network meta-analysis for comparison of efficacy

Abstract: ObjectiveTo compare the efficacy of liver resection (LR), radiofrequency ablation (RFA), and radiofrequency ablation combined with transcatheter arterial chemoembolization (RFA+TACE) in the treatment of very-early- and early-stage hepatocellular carcinoma (HCC).MethodsWe systemically searched the PubMed, Embase, and Cochrane Library databases. Randomized controlled trials (RCTs) and observational analyses with propensity score-matched cohort analyses (PSMs) comparing any two of the three treatments were includ… Show more

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“…Additionally, because RFA can only target locally detectable recurrent lesions, it has poor efficacy for small, undetectable lesions, resulting in a higher risk for recurrence[ 10 ]. In recent years, transcatheter arterial chemoembolization (TACE) has been used to selectively embolize recurrent intrahepatic lesions, effectively solving the problems associated with RFA[ 11 - 14 ]. Therefore, some investigators have proposed that the combination of TACE and RFA (TACE + RFA) may further improve clinical efficacy.…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, because RFA can only target locally detectable recurrent lesions, it has poor efficacy for small, undetectable lesions, resulting in a higher risk for recurrence[ 10 ]. In recent years, transcatheter arterial chemoembolization (TACE) has been used to selectively embolize recurrent intrahepatic lesions, effectively solving the problems associated with RFA[ 11 - 14 ]. Therefore, some investigators have proposed that the combination of TACE and RFA (TACE + RFA) may further improve clinical efficacy.…”
Section: Introductionmentioning
confidence: 99%