Liver retransplantation: Recurrent primary sclerosing cholangitis may provide better outcomes

Choe, Brittany; Mulligan, David C.

doi:10.1002/lt.24777

Liver Transpl

2017

DOI: 10.1002/lt.24777

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Liver retransplantation: Recurrent primary sclerosing cholangitis may provide better outcomes

Brittany Choe

David C. Mulligan

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2024

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Outcome of Liver Retransplantation in Patients With Primary Sclerosing Cholangitis

Molinaro,

Engesæter,

Jorns

et al. 2024

Liver International

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Background and AimsPrimary sclerosing cholangitis (PSC) is among the most common indications for liver transplantation in the Nordic countries and with an increasing trend in Europe and North America. Due to post‐transplant complications and high prevalence of disease recurrence this group is at risk of requiring retransplantation (re‐LTX). Results from re‐LTX for PSC are not extensively studied and there is a lack of knowledge regarding prognosis after re‐LTX in this population.MethodsGraft and patient survival after re‐LTX for patients with PSC and a comparable comparison group from the Nordic liver transplant registry were analysed. One‐hundred and eighty‐five patients with PSC and 208 patients in the comparison group were included.ResultsThe graft and patient survival were better for patients with PSC compared to the comparison group (p < 0.001). Re‐LTX for recurrence of PSC (rPSC) compared to other aetiologies had similar and better outcomes for graft and patient survival (p = 0.093 and p = 0.023, respectively). Moreover, re‐LTX for rPSC compared to the comparison group had a lower 30‐day and 5‐year mortality (p < 0.001 and p = 0.041, respectively).ConclusionOutcomes after retransplantation for PSC were similar or better compared to the comparison group. Retransplantation represents a treatment option with the potential for excellent outcomes in patients with PSC and should be considered in transplanted PSC patients with graft failure.

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Outcome of Liver Retransplantation in Patients With Primary Sclerosing Cholangitis

Molinaro,

Engesæter,

Jorns

et al. 2024

Liver International

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Liver retransplantation: Recurrent primary sclerosing cholangitis may provide better outcomes

Cited by 1 publication

References 11 publications

Outcome of Liver Retransplantation in Patients With Primary Sclerosing Cholangitis

Outcome of Liver Retransplantation in Patients With Primary Sclerosing Cholangitis

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