Liver size evaluated by ultrasound: ROC curves for hepatitis and alcoholism.

Niederau, C; Sonnenberg, Amnon

doi:10.1148/radiology.153.2.6385110

Cited by 17 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…-Liver size was measured as the longitudinal diameter of the right lobe on the midclavicular line (normal values, <12.6 cm) [17]. -Portal vein diameter (PV) was measured at the hilum during deep inspiration.…”

Section: Doppler Sonographymentioning

confidence: 99%

Nonalcoholic fatty liver disease (NAFLD) in nonobese patients with diabetes: Prevalence and relationships with hemodynamic alterations detected with Doppler sonography

Gaiani

Avogaro

Bombonato

et al. 2009

Journal of Ultrasound

View full text Add to dashboard Cite

Aim: To evaluate the prevalence, severity, and hemodynamic features of nonalcoholic fatty liver disease (NAFLD) in nonobese diabetics. Methods: We studied 100 consecutive nonobese (body mass index [BMI] < 30) patients with type 1 (n Z 17) or type 2 (n Z 83) diabetes and no known causes of liver disease. Steatosis was diagnosed and graded with ultrasonography. Digital sonographic images of the liver and right kidney were analyzed with dedicated software (HDI-Lab), and the liver/kidney ratio of grey-scale intensity was calculated as an index of the severity of the steatosis. Severity scores ranging from 0 (none) to 5 (severe) were compared with sonographic and Doppler findings (right liver size, portal vein diameter and flow velocity, hepatic and splenic arterial pulsatility indices, hepatic-vein flow profile and A-and S-wave velocities). Results: The prevalence of steatosis was 24% in type I and 80% in type II diabetes (grade 1 in 17%, grade 2 in 34%, grade 3 in 33%, grade 4 in 9%, grade 5 in 7%). In patients with steatosis (especially those with grades 4e5 disease), hepatic volume was increased (p < 0.005). Portal vein diameter was increased in grade 5 steatosis. The hepatic artery pulsatility index was significantly increased, particularly in grades 4 and 5 (p < 0.0001); portal and A-wave velocities were significantly reduced in grades 3e5 (p < 0.001); and the hepatic vein flow profile was altered in 27% (biphasic: 20%, flat: 7%) patients with steatosis, although there was no correlation with severity. Conclusions: NAFLD is very frequent in nonobese diabetics with type 2 but not type 1 disease, and it is associated with hepatomegaly and liver hemodynamic alterations only when it is severe.

show abstract

Section: Doppler Sonographymentioning

confidence: 99%

Nonalcoholic fatty liver disease (NAFLD) in nonobese patients with diabetes: Prevalence and relationships with hemodynamic alterations detected with Doppler sonography

Gaiani

Avogaro

Bombonato

et al. 2009

Journal of Ultrasound

View full text Add to dashboard Cite

show abstract

“…In contrast, its contribution for assessing chronic diffuse liver disease is more controversial [1], though several characteristic features have been described. These include hepatomegaly [2,3], increased ultrasound attenuation and echo coarseness [4][5][6], quantifiable echo brightness [7], irregular outline of the liver in cirrhotic disease [8,9], portal vein diameter [10, 11], and diminished response of portal vessels to respiration in portal hypertension [11,12]. Secondary extrahepatic signs include ascites, splenomegaly [13,14], etc.…”

mentioning

confidence: 99%

Alcoholic liver disease: Value of the left-to-right portal vein ratio in its sonographic diagnosis

Trigaux

Beers

Buysschaert

et al. 1991

Gastrointest Radiol

View full text Add to dashboard Cite

A study group of 50 patients in whom the left portal vein diameter was equal to or greater than the right portal vein diameter (LPVD greater than or equal to RPVD) was prospectively compared on ultrasonography with a control group of 50 patients with LPVD less than RPVD. Clinical and laboratory data indicating chronic alcoholic liver disease (CALD) were observed with a significantly higher frequency in the study group than in the control group. It emerges from this study that LPVD greater than or equal to RPVD represents a useful ultrasonographic sign of CALD, corresponding to a relative enlargement of the left hepatic lobe compared with the right.

show abstract

“…Similarly, Rosenfield et al [38] defined an upper limit of 15.5 cm MHL height for normal livers. Niederau et al [50] defined the upper normal limit of liver height at the mid-clavicular line to be about 12.7 cm. The standards in [7] and [38] were based on 36 and 33 cases, respectively.…”

Section: Discussionmentioning

confidence: 99%

Assessing Hepatomegaly

et al. 2012

View full text Add to dashboard Cite

Rationale and Objectives To define volumetric nomograms for identifying hepatomegaly and retrospectively evaluate the performance of radiologists in assessing hepatomegaly. Materials and Methods Livers were automatically segmented from 148 abdominal contrast-enhanced CTs: 77 normal and 71 hepatomegaly cases (diagnosed by visual inspection and/or linear liver height by radiologists). Quantified liver volumes were compared to manual measurements using overlap/error (VO/VE). Liver volumes were normalized by patient body-surface-area (BSA) from which hepatomegaly nomograms were defined (H-score) by analyzing the distribution of liver sizes in the healthy population. The H-score was validated against consensus reports. The performance of radiologists in diagnosing hepatomegaly was retrospectively evaluated. Results The automated segmentation of livers was robust with VO/VE of 96.2/2.2%. There were no significant differences (p>0.1) between manual and automated segmentations for either normal/hepatomegaly subgroups. The average volume of normal/enlarged livers was 1.51±0.25/2.32±0.75 liter. One-way ANOVA found BSA (p=0.004) and gender (p=0.02), but not age significantly affected normal liver volume. No significant effects were observed for two-/three-way interactions among the three variables (p>0.18). The H-score cutoffs of 0.92/1.08 l/m2 were used to define mild/massive hepatomegaly (+/−0.02 l/m2 95% CI). Using the H-score as the reference standard, the sensitivity of radiologists in detecting all/mild/massive hepatomegaly was 84.4/56.7/100.0% at 90.1% specificity, respectively. Radiologists disagreed in 20.9% (n=31) of the diagnosed cases. The area under the ROC curve of the H-score criterion for hepatomegaly detection was 0.98. Conclusion Nomograms for the identification and grading of hepatomegaly from automatic volumetric liver assessment normalized by body-surface-area (H-score) were introduced. The H-score matches well with clinical interpretations for hepatomegaly and may improve hepatomegaly detection compared with height measurements or visual inspection commonly used in current clinical practice.

show abstract

Liver size evaluated by ultrasound: ROC curves for hepatitis and alcoholism.

Cited by 17 publications

References 0 publications

Nonalcoholic fatty liver disease (NAFLD) in nonobese patients with diabetes: Prevalence and relationships with hemodynamic alterations detected with Doppler sonography

Nonalcoholic fatty liver disease (NAFLD) in nonobese patients with diabetes: Prevalence and relationships with hemodynamic alterations detected with Doppler sonography

Alcoholic liver disease: Value of the left-to-right portal vein ratio in its sonographic diagnosis

Assessing Hepatomegaly

Contact Info

Product

Resources

About