Liver-specific deficiency of TMEM30A develops spontaneous hepatocellular carcinoma

Liu, Leiming; Xia, Zhiqing; Zhang, Yongming; Su, Jingjing; Sun, Leimin; Zhang, Lingling

doi:10.1093/gastro/goad003

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…Latest research also reported that the TMEM30A liver-specific knockout (LKO) mice showed severe liver damage, including macrophage infiltration and liver fibrosis caused by intrahepatic cholestasis. And DEN + TCPOBOP-induced hepatocellular carcinoma could happen in TMEM30A LKO mice [ 54 ]. So, TMEM30A plays an important role in intrahepatic bile homeostasis.…”

Section: Digestive Systemmentioning

confidence: 99%

Physiological and Pathological Functions of TMEM30A: An Essential Subunit of P4-ATPase Phospholipid Flippases

Zhao²,

Wang

2023

Journal of Lipids

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Phospholipids are asymmetrically distributed across mammalian plasma membrane. The function of P4-ATPases is to maintain the abundance of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in the inner leaflet as lipid flippases. Transmembrane protein 30A (TMEM30A, also named CDC50A), as an essential β subunit of most P4-ATPases, facilitates their transport and functions. With TMEM30A knockout mice or cell lines, it is found that the loss of TMEM30A has huge influences on the survival of mice and cells because of PS exposure-triggered apoptosis signaling. TMEM30A is a promising target for drug discovery due to its significant roles in various systems and diseases. In this review, we summarize the functions of TMEM30A in different systems, present current understanding of the protein structures and mechanisms of TMEM30A-P4-ATPase complexes, and discuss how these fundamental aspects of TMEM30A may be applied to disease treatment.

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Section: Digestive Systemmentioning

confidence: 99%