Liver stiffness assessment by tagged MRI of cardiac‐induced liver motion

Chung, Sohae; Breton, Élodie; Mannelli, Lorenzo; Axel, Leon

doi:10.1002/mrm.22785

Cited by 43 publications

(56 citation statements)

References 31 publications

(34 reference statements)

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“…In addition large standard deviations in the order of the tag period are commonly employed (e.g. [36,39,40]) which reduce the amount of local deformation information obtainable. In the current study 3D magnitude image data is analyzed using a combined 3D Gabor filter bank and scale-space enabling segmentation of tag features while deformation information is maximized using final standard deviations a third of the tag period in magnitude.…”

Section: Discussionmentioning

confidence: 99%

“…A Gabor filter [32] is a Gaussian function modulated by a (possibly complex) harmonic function. Since Gabor filters are also periodically modulated structures they are ideally suited for SPAMM tagged MRI analysis and are increasingly applied for this purpose [33][34][35][36][37][38][39][40][41][42][43]. In Gabor filter analysis an array or bank of filters is applied each with different characteristics (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Gabor filters are most often used for frequency domain and phase analysis and hence in some cases serve as an alternative band-pass filter for HARP type analysis (e.g. [36,40]) which following phase unwrapping enables derivation of displacement estimates. However in many cases the error prone phase unwrapping is avoided and analysis focuses on tracking of the wrapped phase data in which a saw-tooth tag phase modulation is present (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Validation of continuously tagged MRI for the measurement of dynamic 3D skeletal muscle tissue deformation

Moerman¹,

Sprengers²,

Simms³

et al. 2012

Medical Physics

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Purpose: Typically SPAtial Modulation of the Magnetization (SPAMM) tagged MRI requires many repeated motion cycles limiting the applicability to highly repeatable tissue motions only. This paper describes the validation of a novel SPAMM tagged MRI and post-processing frame work for the measurement of complex and dynamic 3D soft tissue deformation following just 3 motion cycles. Techniques are applied to indentation induced deformation measurement of the upper arm and a silicone gel phantom.Methods: A SPAMM tagged MRI methodology is presented allowing continuous (3.3-3.6 Hz) sampling of 3D dynamic soft tissue deformation using non-segmented 3D acquisitions. The 3D deformation is reconstructed by the combination of 3 mutually orthogonal tagging directions, thus requiring only 3 repeated motion cycles. In addition a fully automatic post-processing framework is presented employing Gabor scale-space and filter-bank analysis for tag extrema segmentation and triangulated surface fitting aided by Gabor filter bank derived surface normals. Deformation is derived following tracking of tag surface triplet triangle intersections. The dynamic deformation measurements were validated using indentation tests (~20 mm deep at 12 mm/s) on a silicone gel soft tissue phantom containing contrasting markers which provide a reference measure of deformation. In addition, the techniques were evaluated in-vivo for dynamic skeletal muscle tissue deformation measurement during indentation of the biceps region of the upper arm in a volunteer. Results:For the phantom and volunteer tag point location precision were 44 µm and 92 µm respectively resulting in individual displacements precisions of 61 µm and 91 µm respectively. For both the phantom and volunteer data cumulative displacement measurement accuracy could be evaluated and the difference between initial and final locations showed a mean and standard deviation of 0.44 mm and 0.59 mm for the phantom and 0.40 mm and 0.73 mm for the human data. Finally accuracy of (cumulative) displacement was evaluated using marker tracking in the silicone gel phantom. Differences between true and predicted marker locations showed a mean of 0.35 mm and a standard deviation of 0.63 mm. Conclusions:A novel SPAMM tagged MRI and fully automatic post-processing framework for the measurement of complex 3D dynamic soft tissue deformation following just 3 repeated motion cycles was presented. The techniques demonstrate dynamic measurement of complex 3D soft tissue deformation at sub-voxel accuracy and precision and were validated for 3.3-3.6Hz sampling of deformation speeds up to 12 mm/s.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Validation of continuously tagged MRI for the measurement of dynamic 3D skeletal muscle tissue deformation

Moerman¹,

Sprengers²,

Simms³

et al. 2012

Medical Physics

View full text Add to dashboard Cite

show abstract

“…Moreover, image analysis of MRI bowel data is a complicated, high workload process, which requires dedicated readers and sound statistical analysis (7)(8)(9)(10). The motion encoding technique known as tagged imaging or SPAMM (spatial modulation of the magnetization) was originally developed for cardiac motion (11,12) but has been increasingly used in the abdominal area for measurements of deformation of the liver, distension of the stomach, and gastric activity (13)(14)(15). In SPAMM, a short prepulse sequence periodically saturates the magnetization that will eventually appear as a line or tag pattern in the image.…”

mentioning

confidence: 99%

Use of continuously MR tagged imaging for automated motion assessment in the abdomen: A feasibility study

Sprengers

Paardt

Zijta

et al. 2012

Magnetic Resonance Imaging

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Purpose: To investigate the feasibility of measuring motion in the abdomen using a continuously tagged magnetic resonance imaging sequence. Materials and Methods:To assess (nonperiodic) motion in the abdomen, a nontriggered, continuously tagged transient field echo (TFE) sequence was implemented that acquires one complete 3D dataset per prepulse after a fixed delay. In postprocessing, a frequency analysis approach was developed for compact reviewing of the data and noise suppression. For proof of principle, a simulation was made and one free-breathing dynamic in vivo scan was acquired in a healthy volunteer. During the dynamic scan the volunteer received glucagon intravenously. Results:The simulation showed that this frequency analysis enables the extraction of motion at low signal-tonoise ratio levels. Motion information was successfully gathered from the in vivo scan. The decline in bowel motion caused by the administration of glucagon could be quantitatively measured using the continuously tagged sequence. Conclusion:Continuously tagged imaging in the abdomen for the purpose of automated gathering of motion information is feasible and could aid the study of bowel motion.

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“…Interestingly, MRI permits the use of intrinsic internal body motions rather than externally induced vibration waves in elastography. Cardiac-induced [9] or respiratory-induced [10] motion and deformation of the liver can non-invasively assess liver stiffness related to fibrosis using clinically available imaging tools. Liver stiffness assessed with cardiac-induced liver motion and deformation can also stratify between different Child-Pugh grades of cirrhosis [11] .…”

Section: Liver Stiffnessmentioning

confidence: 99%

Current and Future Magnetic Resonance Technologies for Assessing Liver Disease in Clinical and Experimental Medicine

Bawden

Scott²,

Aithal³

2017

Dig Dis

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Background: In the past decades, a number of non-invasive methods have emerged for detecting and estimating liver fibrosis; these include both serum-based panels and imaging-based technology. Some of these methods are now being incorporated in clinical practice. However, the limitations of the current techniques include lack of organ specificity, sampling errors and limited ability to reflect the efficacy of interventions. Key Messages: Novel magnetic resonance (MR)-based techniques provide an opportunity to bring about further changes in the investigations and management of patients with liver diseases. Multimodal quantitative MR techniques enable the estimation of fat, iron accumulation, degree of liver injury/inflammation and fibrosis within the whole liver without the need for administering contrast agents. Architectural changes within the liver can be evaluated concurrently with portal haemodynamic changes allowing non-invasive assessment of portal hypertension and effects of interventions. A combination ultra-high field (7T) provides greater sensitivity with a potential to distinguish inflammation from fibrosis on imaging and determine specific types of fats (saturated vs. unsaturated) present within the liver using MR spectroscopy. ¹³C MR spectroscopy can estimate glutathione flux and rate of beta oxidation in-vivo providing novel tools for experimental studies that evaluate the efficacy of interventions as well as underlying mechanisms. Conclusions: Translational research should focus on converting the potentials of these innovative methodologies into clinical applications for the benefit of patients.

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Liver stiffness assessment by tagged MRI of cardiac‐induced liver motion

Cited by 43 publications

References 31 publications

Validation of continuously tagged MRI for the measurement of dynamic 3D skeletal muscle tissue deformation

Validation of continuously tagged MRI for the measurement of dynamic 3D skeletal muscle tissue deformation

Use of continuously MR tagged imaging for automated motion assessment in the abdomen: A feasibility study

Current and Future Magnetic Resonance Technologies for Assessing Liver Disease in Clinical and Experimental Medicine

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