Liver stiffness is able to differentiate hepatosplenic Schistosomiasis mansoni from liver cirrhosis and spleen stiffness may be a predictor of variceal bleeding in hepatosplenic schistosomiasis

Silva, Catherine F; Nardelli, Mateus Jorge; Barbosa, Fernanda A; Galizzi, Humberto O; Cal, Tereza Cristina Minto Fontes; Ferrari, Teresa C. A.; Faria, Luciana Costa; Couto, Cláudia Alves

doi:10.1093/trstmh/trab041

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…In fact, recent studies have shown that the measurement of spleen stiffness by TE and pSWE correlates with that of liver stiffness and of portal hypertension in patients with HSS[ 20 , 52 ]. Accordingly, spleen stiffness may also be a predictor of variceal bleeding in HSS and may be further investigated for predicting HSS complications[ 57 ].…”

Section: Noninvasive Markers Of Ppfmentioning

confidence: 99%

Noninvasive diagnosis of periportal fibrosis in schistosomiasis mansoni: A comprehensive review

Santos¹,

Pereira²,

Domingues³

et al. 2022

WJH

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Schistosomiasis mansoni is a neglected disease and key public health problem, mainly due to its high prevalence, the scarcity of public policies, and the severity of some clinical forms. Periportal fibrosis (PPF) is the commonest complication of chronic schistosomiasis mansoni and its diagnosis requires different techniques. Even though wedge biopsy of the liver is considered the gold standard, it is not justified in non-surgical patients, and percutaneous liver biopsy may be informative but does not have sufficient sensitivity. Noninvasive PPF tests mostly include biological (serum biomarkers or combined scores) or physical assessments (imaging assessment of fibrosis pattern or tissue stiffness). Moreover, imaging techniques, such as ultrasound, computed tomography, magnetic resonance imaging, and elastography are applied not only to support the diagnosis of schistosomiasis, but also to assess and detect signs of portal hypertension and organ damage due to chronic schistosomiasis. A combination between a comprehensive history and physical examination with biomarkers for liver fibrosis and imaging methods seems to offer the best approach for evaluating these patients. In addition, understanding their strengths and limitations will allow a more accurate interpretation in the clinical context and can lead to greater accuracy in estimating the degree of fibrosis in patients with Schistosomiasis mansoni (S. mansoni) infection. This review will discuss the different noninvasive methods that are currently available for the evaluation of PPF in S. mansoni infection, and their application, advantages, and limitations in clinical practice.

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Section: Noninvasive Markers Of Ppfmentioning

confidence: 99%

Noninvasive diagnosis of periportal fibrosis in schistosomiasis mansoni: A comprehensive review

Santos¹,

Pereira²,

Domingues³

et al. 2022

WJH

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“…Transient elastography-FibroScan quantitatively evaluates liver fibrosis by measuring LSM using a shear wave technique[ 88 ]. Its non-invasive diagnostic efficacy for liver fibrosis has been verified in a variety of causes of chronic liver disease[ 85 , 89 ].…”

Section: Value Of Liver Stiffness Measurement During Early Hsct-sos D...mentioning

confidence: 99%

Early diagnostic value of liver stiffness measurement in hepatic sinusoidal obstruction syndrome induced by hematopoietic stem cell transplantation

Ya¹,

Shi²

2022

WJCC

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Hematopoietic stem cell transplantation (HSCT)-sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease, is a clinical syndrome characterized by symptoms, such as right upper quadrant pain, jaundice, fluid retention, and hepatomegaly, and is caused by pre-treatment-related hepatotoxicity during the early stages after HSCT. Clinical diagnosis of HSCT-SOS is based on the revised Seattle or Baltimore standards. The revised standard by the European Society for Bone Marrow Transplantation in 2016 has good practicability and can be used in combination with these two standards. Eight studies have shown the value of liver stiffness measurement (LSM) in the early diagnosis of HSCT-SOS. Four studies investigated LSM specificity and sensitivity for the early diagnosis of HSCT-SOS. LSM can distinguish SOS from other post-HSCT complications, enabling a clear differential diagnosis. It has been shown that median LSM of patients with SOS is significantly higher than that of patients with other treatment-related liver complications ( e.g ., acute cholecystitis, cholangitis, antifungal drug-related liver injury, liver graft-versus-host disease, isolated liver biochemical changes, and fulminant Epstein Barr virus related hepatitis reactivation). Therefore, the above data confirmed the utility of LSM and strongly suggested that LSM improves the positive predictive value of the SOS diagnostic clinical score after allogeneic HSCT. Early diagnosis of SOS is beneficial in preventing severe HSCT complications.

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Liver stiffness is able to differentiate hepatosplenic Schistosomiasis mansoni from liver cirrhosis and spleen stiffness may be a predictor of variceal bleeding in hepatosplenic schistosomiasis

Cited by 2 publications

References 27 publications

Noninvasive diagnosis of periportal fibrosis in schistosomiasis mansoni: A comprehensive review

Noninvasive diagnosis of periportal fibrosis in schistosomiasis mansoni: A comprehensive review

Early diagnostic value of liver stiffness measurement in hepatic sinusoidal obstruction syndrome induced by hematopoietic stem cell transplantation

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