Liver stores of vitamin A in human fetuses in relation to gestational age, fetal size and maternal nutritional status

Shah, Raksha S.; Rajalakshmi, R.; Bhatt, Rohit; Hazra, M; Patel, Bianca; Swamy, Narayana; Patel, T. V.

doi:10.1079/bjn19870085

Cited by 43 publications

(22 citation statements)

References 13 publications

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“…16 This is in agreement with other reports that emphasize the vital role of vitamin A in the fetal growth. 17,18 Significant correlation was seen between maternal and cord serum vitamin A levels as seen in previous studies. 14,16 This suggests influence of maternal vitamin A status on the infant's vitamin A levels.…”

Section: Discussionsupporting

confidence: 62%

Factors affecting serum vitamin a levels in matched maternal-cord pairs

et al. 2008

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Data from our study show that prematurity and intrauterine growth retardation are associated with low neonatal vitamin A levels. Several factors like lack of ANC, lower maternal Hb levels and reduced placental weight further affect vitamin A status of the newborn rendering them highly susceptible to vitamin A deficiency. We therefore, suggest further studies on vitamin A supplementation in pregnant women and preterm neonates.

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Section: Discussionsupporting

confidence: 62%

Factors affecting serum vitamin a levels in matched maternal-cord pairs

et al. 2008

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“…However, by mid-organogenesis the retinoid content of the embryo exceeds that of the placenta. The data reported from mouse are in general agreement with those reported for humans and other species [80, 81]. …”

Section: Vitamin a And Developmentsupporting

confidence: 89%

Maternal–fetal transfer and metabolism of vitamin A and its precursor β-carotene in the developing tissues

Spiegler

Kim

Wassef

et al. 2012

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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The requirement of the developing mammalian embryo for retinoic acid is well established. Retinoic acid, the active form of vitamin A, can be generated from retinol and retinyl ester obtained from food of animal origin, and from carotenoids, mainly β-carotene, from vegetables and fruits. The mammalian embryo relies on retinol, retinyl ester and β-carotene circulating in the maternal bloodstream for its supply of vitamin A. The maternal-fetal transfer of retinoids and carotenoids, as well as the metabolism of these compounds in the developing tissues are still poorly understood. The existing knowledge in this field has been summarized in this review in reference to our basic understanding of the transport and metabolism of retinoids and carotenoids in adult tissues. The need for future research on the metabolism of these essential lipophilic nutrients during development is highlighted.

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“…The correlation between maternal and cord serum retinol was highly statistically significant (r=0.37, p<.0001). In another study, maternal serum retinol was highly correlated with fetal liver retinol at gestational age <24 weeks (r=0.59, p<.01), and this correlation increased to 0.83 (p<.001) for >24 weeks (Shah et al, 1987). …”

Section: Discussionmentioning

confidence: 94%

Low maternal retinol as a risk factor for schizophrenia in adult offspring

Bao

Ibram

Blaner

et al. 2012

Schizophrenia Research

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Background Prenatal micronutrient deficiency has been linked to later development of schizophrenia among offspring; however, no study has specifically investigated the association between vitamin A and this disorder. Vitamin A is an essential nutrient which is required by the early embryo and fetus for gene expression and regulation, cell differentiation, proliferation and migration. Previous work suggests that vitamin A deficiency in the second trimester may be particularly relevant to the etiopathogenesis of neurobehavioral phenotypes some of which are observed in schizophrenia. Methods We examined whether low maternal vitamin A levels in the second trimester are associated with the risk of schizophrenia and other schizophrenia spectrum disorders (SSD) in the Prenatal Determinants of Schizophrenia study; third trimester vitamin A levels were also examined in relation to SSD. The cases were derived from a population-based birth cohort; all cohort members belonged to a prepaid health plan. Archived maternal serum samples were assayed for vitamin A in cases (N=55) and up to 2 controls per case (N=106) matched on length of membership in the health plan, date of birth (±28 days), sex, and gestational timing and availability of archived maternal sera. Results For the second trimester, low maternal vitamin A, defined as values in the lowest tertile of the distribution among controls, was associated with a greater than threefold increased risk of SSD, adjusting for maternal education and age (OR=3.04, 95% CI=1.06, 8.79, p=.039). No association between third trimester maternal vitamin A and SSD was observed. Conclusions Although further investigations are warranted, this is the first birth cohort study to our knowledge to report an association between low maternal vitamin A levels and SSD among offspring.

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Liver stores of vitamin A in human fetuses in relation to gestational age, fetal size and maternal nutritional status

Cited by 43 publications

References 13 publications

Factors affecting serum vitamin a levels in matched maternal-cord pairs

Factors affecting serum vitamin a levels in matched maternal-cord pairs

Maternal–fetal transfer and metabolism of vitamin A and its precursor β-carotene in the developing tissues

Low maternal retinol as a risk factor for schizophrenia in adult offspring

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