Liver Transplant Using a Severely Lacerated Graft Treated by Arterial Embolization

Lai, Quirino; Ferretti, Stefano; Rossi, Massimo; Berloco, P.B.

doi:10.6002/ect.2012.0185

Cited by 6 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A rabbit study [219] of temporary occlusion and a separate large series of patients [222] with permanent occlusion supported the use of fibrin sealant for hepatic embolectomy. Finally, a case report of using fibrin sealant to facilitate preimplantation repair of a lacerated donor liver to assure successful transplant appeared [215]. …”

Section: Less Frequently Published Clinical Applications Of Fibrinmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

View full text Add to dashboard Cite

Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

show abstract

Section: Less Frequently Published Clinical Applications Of Fibrinmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

View full text Add to dashboard Cite

show abstract

“…There have been several individual case reports of whole-organ transplants with high grade lacerations. Lacerated livers have been managed by a combination of sealants, glue, suturing, packing, or arterial embolization [1,3,4]. In our case, we employed a similar evaluation and management strategy to that used in our living donor assessments.…”

Section: Discussionmentioning

confidence: 99%

“…As such, many centers exclude donors with known grade 4 and 5 liver injuries from consideration for donation. Moreover, limited reports exist of the use of these livers [1,[3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Utilization of a Reduced Graft from a Severely Traumatized Liver: A Case Report and Strategy to Increase Availability of Livers for Transplant

Imai¹,

Kumaran²,

Bruno³

et al. 2021

SCR

View full text Add to dashboard Cite

Background: Trauma victims with liver lacerations in the hilum are typically excluded from liver donation. We report a case of a successful liver transplant from a deceased donor with a grade 4 hilar liver laceration. Case Presentation: We used a liver with a high-grade laceration from a 28-year-old brain-dead traffic accident victim. The liver had grade IV lacerations in the right and caudate lobes. In situ split liver technique was applied to control the lacerations after an intraoperative cholangiogram revealed favourable anatomy. The left hemi-liver graft was procured, retaining the entire vena cava and the full length of the main hepatic vasculature. The recipient was a 62-year-old female patient with end-stage liver disease, with a Model for End-Stage Liver Disease-Sodium score of 19. The left lobe graft was transplanted using the standard piggy-back technique. The patient was discharged on postoperative day 7 after an uneventful recovery. At two-month follow-up, she continues to do well, with normal hepatic function and unremarkable imaging studies. Conclusion: This is the first reported case of a successful liver transplant of a severely lacerated liver made possible by the application of split liver techniques. In situ splitting of a severely traumatized liver could permit the utilization of a reduced graft for small recipients.

show abstract

“…However, livers with low-grade parenchymal injury may be considered as graft candidates. [5][6][7][8][9][10] The first successful use of a liver from an open abdomen was reported by Grezzana and associates. 12 The donor was pronounced brain dead 6 days after laparotomy.…”

Section: Discussionmentioning

confidence: 99%

“…There have been several reports about successful use of traumatized liver graft, [5][6][7][8][9][10] but few reports have documented the use of donations from an open abdomen setting, 11,12 where infection is a concern due to the hostile environment, and only one such report documented a good outcome. The open abdomen is one of the damage control techniques performed in life-threatening situations, in which abdominal closure is delayed until hypothermia, metabolic acidosis, and coagulopathy are corrected and hemodynamics are stable.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Junrungsee

Ongprasert²,

Ko-iam³

et al. 2018

Exp Clin Transplant

View full text Add to dashboard Cite

Donor scarcity is a primary problem in the development of a transplant program. The imbalance between an extremely increasing demand and the number of organs in the supply has led to an extended criteria donor approach. The successful use of donors with infectious diseases and septic shock has been reported. However, organs from deceased donors with traumatic abdominal injury and open abdomen are usually discarded due to risks of severe infections. Thus far, only 1 such case, in which a liver graft from an open abdomen was used successfully, has been reported. Herein, we report of a case of liver transplant using a traumatized liver allograft procured from a deceased donor with an open abdomen. The donor was a 16-year-old patient who had blunt abdominal trauma and severe head injury from a car accident, resulting in emergency laparotomy with suturing of the lacerated wound at the liver and abdominal packing. The donor was subsequently pronounced brain dead, and the family consented to organ donation. A multiorgan procurement was performed, and the liver was transplanted to 52-year-old patient who had multiple hepatocellular carcinomas. The postoperative course was without any infection or rejection. In conclusion, the use of donor livers with preexisting trauma in open abdomen settings can be used as alternative to expand the organ donor pool.

show abstract

Liver Transplant Using a Severely Lacerated Graft Treated by Arterial Embolization

Cited by 6 publications

References 11 publications

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Utilization of a Reduced Graft from a Severely Traumatized Liver: A Case Report and Strategy to Increase Availability of Livers for Transplant

Untitled

Contact Info

Product

Resources

About