Liver transplantation and HBsAg-positive postnecrotic cirrhosis: adequate immunoprophylaxis and delta virus co-infection as the significant determinants of long-term prognosis

Liver transplantation for hepatitis B virus-related liver disease: Indications, prevention of recurrence and results

“…HBV recurrence rate was dependent of the presence of HBV replication assessed by both serum HBeAg and HBV DNA detection using conventional hybridisation technique at time of transplantation [5]. These results were confirmed by others clinical trials in the US and Europe and by long-term follow-up studies (Table 1 and 2) [14,[24][25][26][27][28][29][30].…”

Failure of a reinforced triple course of hepatitis B vaccination in patients transplanted for HBV-related cirrhosis

“…1-2 The introduction of the long-term use of anti-HBs immune globulins (HBIg) has allowed the reduction of graft reinfection to acceptable levels, resulting in survival rates comparable with, or even better than, those of other indications. [3][4][5] This passive immunoprophylaxis strategy is therefore currently considered the standard treatment to prevent HBV reinfection after liver transplantation for HBV-related cirrhosis. 6 Yet, using this approach, posttransplant HBV recurrence still occurs in 10% to 30% of cases, possibly depending on a variety of factors, such as the amount of HBIg infused, the route and frequency of administration, and the minimum trough levels of anti-HBs maintained during various periods after transplant.…”

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“…29,31,32 The presence of HDV infection appears to provide a protective effect against HBV reinfection, possibly via suppression of HBV replication. 33 In contrary to the well-known belief that the presence of HDV suppressed HBV replication, a recent study showed a higher degree of replicative activity of either or both viruses.…”