Liver transplantation for alcoholic hepatitis: a systematic review with meta-analysis

Abstract

BackgroundThe rate of alcohol relapse among patients who underwent liver transplantation for alcoholic hepatitis (AH) is not precisely known. AimSynthesize the available evidence on liver transplantation for AH to assess alcohol relapse and 6-month survival. MethodsMeta-analysis of trials evaluating liver transplantation for AH, either clinically severe or diagnosed on the explant. OPEN ACCESS Citation: Marot A, Dubois M, Trépo E, Moreno C, Deltenre P (2018) Liver transplantation for alcoholic hepatitis: A systematic review with metaanalysis. PLoS ONE 13(1): e0190823. https://doi. ConclusionUsing stringent selection criteria, 14% of patients with clinically severe AH have alcohol relapse after liver transplantation. The percentage of alcohol relapse of AH transplanted patients is similar than that of patients who underwent elective liver transplantation. DF, Maddrey's discriminant function; NA, not available; OR, odds ratio.