Liver Transplantation for Fulminant Hepatic Failure

Early Evidence of Bone Marrow Dysfunction in Children with Indeterminate Fulminant Hepatic Failure Who Ultimately Develop Aplastic Anemia

“…The causes of FHF vary geographically and are also age-dependent. In the United Kingdom the most frequent pediatric cause of FHF is acetaminophen toxicity, whereas most children in the United States have the indeterminate type (4)(5)(6). Liver transplantation (LTx) remains the only definitive mode of treatment for individuals with FHF who fail to recover spontaneously.…”

Outcome from molecular adsorbent recycling system (MARS™) liver dialysis following drug‐induced liver failure

“…This can be circumvented or even reversed with timely liver transplantation. Various centers in Europe and USA have reported their results for liver transplantation in fulminant liver failure, and they range from 58% to 92% (4–9). However, in Asia, the availability of cadaveric liver donors have limited the utility of liver transplantation for the treatment of acute liver failure.…”

Between Scylla and Charybdis

“…Our own experience over the last decade, in which fulminant and subfulminant hepatic failure accounted for <3% of the total case load, has been similar to that of the Paris team. 5 However, for the reasons discussed by Bismuth et al,3 we do not use ABO incompatible, steatotic, or otherwise marginal livers for these very ill patients. The survival and avoidance of retransplantation hinges more on achieving good function promptly than on promptly receiving a graft that would not be acceptable for the average candidate with end-stage chronic disease.…”