Liver transplantation for hepatic and neurological wilson’s disease

Neurological manifestations in Wilson’s disease –possible treatment options for symptoms

“…[72] In this study, neurological improvement or stabilization was observed in 78% of patients, whereas four patients (10%) died from LT complications. At other centers, Geissler et al found that only 33% (2/6) of patients with WD had improvement of neurological symptoms after LT. [75] In contrast, Wang et al reported excellent outcomes, with recovery of neurological deficits in 88% (8/9) of patients. [68] Furthermore, analysis of 37 transplanted patients in Italy showed that the presence of neuropsychiatric symptoms in patients with WD indicated for LT was associated with a worse outcome (i.e.…”

“…Currently, only case reports describing LT as a treatment for neurological symptoms in patients with WD have been published, with conflicting results. [67][68][69][70][71][72][73][74][75][76][77][78][79] Stracciari et al reported on 41 patients with WD and neurological symptoms who underwent LT; however, only 5 cases were transplanted because of neurological deterioration while the remaining cases were transplanted because of hepatic indications. [72] In this study, neurological improvement or stabilization was observed in 78% of patients, whereas four patients (10%) died from LT complications.…”

Auxiliary Partial Orthotopic Living Donor Liver Transplantation in a Patient With Wilson's Disease: A Case Report

“…Orthotopic liver transplantation (OLT) has been demonstrated to be a valuable treatment option in cases of fulminant hepatic failure and advanced cirrhosis. 1 Auxiliary partial orthotopic liver transplantation (APOLT) has been performed for fulminant hepatic failure, noncirrhotic metabolic disease, sizemismatched grafts, and ABO-incompatible grafts. 2 Herein we have reported a case of successful living donor-related APOLT using a right lobe in a patient with liver cirrhosis and neurologic disease associated with WD.…”

Morbus Wilson

“…Al ler dings kommt sie nur bei aku tem Le ber ver sa gen so wie bei fortge schrit te ner Le ber zir rho se in Fra ge, da die mög li chen Kom pli ka tio nen und die le bens lang not wen di ge Im mun sup pres sion er heb li che Ri si ken ber gen. Ver schie dene Fall be rich te be le gen auch eine Ver besse rung von in ku ra blen neu ro lo gi schen Symp to men [27,28]. Aus den mo men tan ver füg ba ren Da ten kann je doch kei ne allge mei ne In di ka ti on ab ge lei tet wer den und eine Le ber trans plan ta ti on zur The rapie schwe rer the ra pie re frak tä rer neu ro lo gischer Symp to me er scheint nur in Ein zel fäl-len ge recht fer tigt [20,21].…”