Liver transplantation for metastatic colorectal cancer (case report)

Deceased brain-dead donor liver transplantation (LT) is a high-risk intervention. The outcome depends on a large number of modifiable and non-modifiable factors. Objective: to analyze our own experience and identify preoperative and perioperative prognostic factors for poor outcomes in LT. Materials and methods. The study included 301 liver transplants performed between January 2016 and December 2021. Donor and recipient characteristics, intraoperative data, perioperative characteristics including laboratory test data, and the nature and frequency of complications were used for the analysis. Results. The 1-, 3- and 5-year recipient survival rates were 91.8%, 85.1%, and 77.9%, respectively; graft survival rates were 90.4%, 83.7%, and 76.7%, respectively. The most significant predictors of poor outcome of LT on the recipient side were biliary stents (HR 7.203, p < 0.01), acutely decompensated cirrhosis (HR 2.52, p = 0.02); in the postoperative period, non-surgical infectious complications (HR 4.592, p < 0.01) and number of reoperations (HR 4.063, p < 0.01). Donor creatinine level (HR 1.004, p = 0.01, one factor analysis; HR 1.004, p = 0.016, multivariate analysis) was the only reliable prognostic negative factor. Conclusion. LT taking into account established risk factors will improve surgery outcomes and help personalize the therapy for each patient.

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Risk factors in deceased donor liver transplantation: a single centre experience

Zubenko

Monakhov

Boldyrev

et al. 2022

RJTAO

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Colorectal cancer liver metastases: current state of the problem, priority treatment approaches

Aliyev¹,

Алиев²

2022

Khir. Z. im. N.I. Pirogova

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Colorectal liver metastases: global trends in epidemiology, modern opportunities for treatment

Aliyev¹,

Алиев²

2021

Onkol. Z. im. P.A. Gercena

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Liver transplantation for metastatic colorectal cancer (case report)

Cited by 3 publications

References 33 publications

Risk factors in deceased donor liver transplantation: a single centre experience

Risk factors in deceased donor liver transplantation: a single centre experience

Colorectal cancer liver metastases: current state of the problem, priority treatment approaches

Colorectal liver metastases: global trends in epidemiology, modern opportunities for treatment

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