Liver Transplantation for Treatment of Giant Hepatocellular Adenomas

Mueller, Juergen; Keeffe, Emmet B.; Esquivel, Carlos O.

doi:10.1002/lt.500010205

Cited by 28 publications

(19 citation statements)

References 21 publications

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“…If patient presents with multiple hepatic adenoma, complete resection may be impossible, and hepatic transplantation is taken into consideration when tumors progress. 21 Malignant transformations is rare, but there have been a few cases reported. 22 In one series of 39 cases of unresected liver adenoma, 5 cases subsequently developed hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Adenoma - A Case Report

et al. 2016

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We report the case of a 32-year-old female who presented to us with incidental findings of a space occupying lesion (SOL) in liver on abdominal ultrasound (USG). She was taking oral contraceptive pill for last 9 years. Clinical examination was unremarkable and liver investigation revealed mildly raised Serum alanine aminotrasferase (ALT). Dyslipidemia was also present. Computed tomography (CT) identified a 2.5 cm lesion in the right lobe of liver at posterior aspect which was isodense. Alpha-feto protein was normal. CT guided Fine Needle Aspiration Cytology (FNAC) showed adequate cellular material containing organized reactive hepatocytes in the background of blood. No granuloma or malignant cell was seen. Findings were suggestive of hepatic adenoma.Birdem Med J 2015; 5(1) Supplement: 59-62

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Section: Discussionmentioning

confidence: 99%

Hepatic Adenoma - A Case Report

et al. 2016

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“…The risk of malignant transformation to hepatocellular carcinoma is 5-10% [1,5]. The natural history of tumor is uncertain, and thus the spectrum of treatment of hepatic adenomas range from careful observation with cessation of oral contraceptives to liver resection to orthotopic liver transplantation in unresectable cases [5,8].…”

Section: Discussionmentioning

confidence: 99%

Orthotopic Liver Transplantation for Hepatic Adenoma in a Patient with Portal Vein Agenesis

Sibulesky¹,

Taner²,

Willingham³

et al. 2009

TOTRANSJ

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Congenital portal vein agenesis, known as the Abernathy malformation, was first described in 1793. It is associated with focal nodular hyperplasia and adenomas due to abnormal hepatic regeneration secondary to abnormal or absent flow to the liver. We report a case of a 25-year-old Caucasian female with a complicated medical history including idiopathic membranoproliferative glomerulonephritis, hypertension, hyperlipidemia, Sweet's syndrome, acute febrile neutrophilic dermatosis, who incidentally was diagnosed with multiple liver nodules, the largest 14 cm in diameter, arising at the junction of the left and right hepatic lobes. She was also noted to have a congenital absence of the portal vein. There was no evidence of cirrhosis or portal hypertension. Liver function tests and -fetoprotein were within normal limits. A biopsy of the largest mass revealed hepatocellular adenoma. Because of the size, location, and multiplicity of the lesions, we elected to proceed with orthotopic liver transplantation. She subsequently underwent deceased donor liver transplantation using the piggyback technique. Despite dividing the portal vein shunt after completion of the caval anastomosis and minimizing the portal vein clamp time, her spleen spontaneously ruptured, for which splenectomy was performed. The patient did well postoperatively with good liver function.

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“…Surgical treatments such as lobectomy [21,33] , enucleation [34] and liver transplantation [35] are perfor med for LCA. Percutaneous ethanol injection [20] and transcatheter arterial embolization [33] are established therapies for low invasive treatment of HCC, and were reported to be performed for LCA.…”

Section: Discussionmentioning

confidence: 99%

Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma

Kogure

Ueno²,

Sekiguchi³

et al. 2009

WJG

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A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral contraceptives. Radiological diagnostics showed the typical findings of liver cell adenoma (LCA). Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in the arterial phase and almost the same enhancement as the surrounding liver parenchyma in the delayed phase. The tumor was found to contain fat on magnetic resonance imaging. A benign fat containing liver tumor was suggested. However, radiological findings altered, which caused us to suspect that a welldifferentiated hepatocellular carcinoma (HCC) containing fat was becoming dedifferentiated. Partial hepatectomy was performed and the pathological findings showed the typical findings of LCA. This case was an extremely rare LCA, which had no background of risk for LCA and developed the sequential alteration of the radiological findings to suspect well-differentiated HCC.

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Liver Transplantation for Treatment of Giant Hepatocellular Adenomas

Cited by 28 publications

References 21 publications

Hepatic Adenoma - A Case Report

Hepatic Adenoma - A Case Report

Orthotopic Liver Transplantation for Hepatic Adenoma in a Patient with Portal Vein Agenesis

Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma

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