Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature

Robinson, Todd J.; Cummins, Kaelyn; Tsung, Allan

doi:10.3390/curroncol31020080

Cited by 3 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Colorectal cancers are known to be the most common concurrent cancers in patients with stomach cancer [ 4 ]. Colorectal cancer is the third most common type of cancer in the world [ 5 ]. The relationship between stomach polyps and colon cancer is an important one due to its frequency.…”

Section: Introductionmentioning

confidence: 99%

Gastric Polyps Detected Incidentally during Gastroscopy and Follow-Up Results

Gul,

Oguz Aslayan,

Corbaci

et al. 2024

JCM

View full text Add to dashboard Cite

(1) Background: We aimed to identify the possible relationship between various diseases of the upper digestive system and colon polyps by analyzing patients with gastric polyps and evaluating the cancers and diseases accompanying the polyps. (2) Methods: Each patient’s age; gender; polyp type and size; presence of Helicobacter pylori (H. pylori), atrophic gastritis, and intestinal metaplasia; status of whether cancer developed during follow-up; status of whether a colonoscopy was performed or not; and colon pathologies detected during colonoscopy were analyzed retrospectively using hospital records. (3) Results: Between the study dates, 19,214 esophagogastroduodenoscopies were performed in the endoscopy unit of our hospital. Gastric polyps were detected in 178 (0.9%) patients. No significant relationship was found between the gastric polyp size and the occurrence of gastric cancer or gastrointestinal system malignancy (p > 0.05). A colonoscopy was performed in 86 of the 178 patients who underwent gastroscopy. The frequency of polyp detection during colonoscopy was statistically significantly higher in patients with gastric polyps than in patients without gastric polyps (p < 0.001). (4) Conclusions: New prospective studies are needed regarding the relationship between gastric polyps and gastrointestinal system diseases. Going forward, a colonoscopy will be required in gastric polyp patients, especially with FGP.

show abstract

Section: Introductionmentioning

confidence: 99%

Gastric Polyps Detected Incidentally during Gastroscopy and Follow-Up Results

Gul,

Oguz Aslayan,

Corbaci

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

Role of locoregional therapy including liver transplantation in liver-only metastatic colorectal cancer: a review Paper

Depauw,

Townsend,

Karapetis

et al. 2024

Expert Review of Anticancer Therapy

View full text Add to dashboard Cite

Challenges and Opportunities for Precision Surgery for Colorectal Liver Metastases

O’Connell,

Hoti

2024

Cancers

View full text Add to dashboard Cite

The incidence of colorectal cancer and colorectal liver metastases (CRLM) is increasing globally due to an interaction of environmental and genetic factors. A minority of patients with CRLM have surgically resectable disease, but for those who have resection as part of multimodal therapy for their disease, long-term survival has been shown. Precision surgery—the idea of careful patient selection and targeting of surgical intervention, such that treatments shown to be proven to benefit on a population level are the optimal treatment for each individual patient—is the new paradigm of care. Key to this is the understanding of tumour molecular biology and clinically relevant mutations, such as KRAS, BRAF, and microsatellite instability (MSI), which can predict poorer overall outcomes and a poorer response to systemic therapy. The emergence of immunotherapy and hepatic artery infusion (HAI) pumps show potential to convert previously unresectable disease to resectable disease, in addition to established systemic and locoregional therapies, but the surgeon must be wary of poor-quality livers and the spectre of post-hepatectomy liver failure (PHLF). Volume modulation, a cornerstone of hepatic surgery for a generation, has been given a shot in the arm with the advent of liver venous depletion (LVD) ensuring significantly more hypertrophy of the future liver remnant (FLR). The optimal timing of liver resection for those patients with synchronous disease is yet to be truly established, but evidence would suggest that those patients requiring complex colorectal surgery and major liver resection are best served with a staged approach. In the operating room, parenchyma-preserving minimally invasive surgery (MIS) can dramatically reduce the surgical insult to the patient and lead to better perioperative outcomes, with quicker return to function.

show abstract

Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature

Cited by 3 publications

References 40 publications

Gastric Polyps Detected Incidentally during Gastroscopy and Follow-Up Results

Gastric Polyps Detected Incidentally during Gastroscopy and Follow-Up Results

Role of locoregional therapy including liver transplantation in liver-only metastatic colorectal cancer: a review Paper

Challenges and Opportunities for Precision Surgery for Colorectal Liver Metastases

Contact Info

Product

Resources

About