2015
DOI: 10.4254/wjh.v7.i19.2229
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Liver transplantation in a patient with primary antiphospholipid syndrome and Budd-Chiari syndrome

Abstract: The antiphospholipid syndrome (APS) is an acquired thrombophilic disorder in which autoantibodies are produced to a variety of phospholipids determinants of cell membranes or phospholipid binding proteins. There are few reports about association between antiphospholipid antibodies and development of Budd-Chiari syndrome (BCS). We report the case of BCS development in young Russian male with primary APS. The patient underwent orthotopic liver transplantation on August 26, 2012. At present time his state is good… Show more

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Cited by 19 publications
(7 citation statements)
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“…The factors that cause BCS include chronic myeloproliferative syndromes (MPS), such as polycythemia vera, ET, paroxysmal nocturnal hemoglobinuria, hematologic and liver metabolic abnormalities, such as deficit of antithrombin, protein C and protein S, resistance to protein C activated, mutation of factor V Leiden, mutation G20210A of the gene that codifies the factor II, neoplasias, administration of oral contraceptive, pregnancy and the period of postpartum. The most frequent factor of risk prothrombotic is MPS, even if it was proved that almost half of the patients have multiple factors of risk prothrombotic [12][13][14]. Among the factors that cause it mentioned above, ET is associated with high risk of deep vein thrombosis.…”
Section: Resultsmentioning
confidence: 99%
“…The factors that cause BCS include chronic myeloproliferative syndromes (MPS), such as polycythemia vera, ET, paroxysmal nocturnal hemoglobinuria, hematologic and liver metabolic abnormalities, such as deficit of antithrombin, protein C and protein S, resistance to protein C activated, mutation of factor V Leiden, mutation G20210A of the gene that codifies the factor II, neoplasias, administration of oral contraceptive, pregnancy and the period of postpartum. The most frequent factor of risk prothrombotic is MPS, even if it was proved that almost half of the patients have multiple factors of risk prothrombotic [12][13][14]. Among the factors that cause it mentioned above, ET is associated with high risk of deep vein thrombosis.…”
Section: Resultsmentioning
confidence: 99%
“…Причиной поражения печени у этих больных были тромбофилические состояния (атипичный гемолитикоуремический синдром и наследственная тромбофилия). По данным литературы, поражение печени при наследственных и приобретенных тромбофилиях (среди которых основное место занимает АФС) чаще связано с развитием тромбозов печеночной артерии, воротной и печеночных вен, что может требовать проведения трансплантации печени [19,20]. По нашим данным, поражение печени у 2 пациенток не было вызвано гемодинамически значимым тромбозом крупных сосудов печени.…”
Section: Discussionunclassified
“…Liver transplant recipients represent a particularly complex population owing to their unique hemostatic physiology and variable metabolic function. Patients with clinically significant liver disease were generally excluded from randomized‐controlled trials that lead to FDA approval of the DOACs, and present published experience with DOAC use in liver transplant recipients has been limited to one small case series and several single case reports …”
Section: Discussionmentioning
confidence: 99%