Liver Transplantation in Adults With Liver Disease Due to Common Variable Immunodeficiency Leads to Early Recurrent Disease and Poor Outcome

Common Variable Immunodeficiency Enteropathy and Its Unpredictable Biopsy Findings: Not Everything Is Black and White

“… 10 It is important to keep patients with CVID on long-term follow-up as the chances of developing granulomatous diseases, lymphoproliferative disorders, and malignancies are high. 11 , 12 Prompt recognition and conscientious treatment of opportunistic infections with timely replacement of immunoglobulins are the mainstays of therapy. These patients need close clinical follow-up and continuous antimicrobial prophylaxis unless they undergo stem cell transplantation.…”

Heterogeneity of Liver Disease in Common Variable Immunodeficiency Disorders

“…On the other hand, the theoretical increase of infectious and neoplastic risk related to the long-term concomitant immunosuppressive therapy has historically determined a reluctance to perform LT in CVID patients. In the last decade, a growing number of reports described the outcome of LT performed in adult and pediatric CVID patients with viral hepatitis or NRH (137)(138)(139)(140)(141)(142)(143).…”

Immunosuppression Withdrawal After Liver Transplantation for Common Variable Immunodeficiency

“…These severe complications often lead to early posttransplant death, and thereby, might produce questions about the indication of LT in CVID patients. (4,5) A 59-year-old male patient suffering from CVID was evaluated for LT in 2016 because of cirrhosis with portal hypertension and ascites. The patient had been suffering from recurrent infections of the upper respiratory tract since the age of 20 years.…”

“…This patient's case might provide new insight into the management of CVID patients with ESLD, and the patient underwent LT in early 2017, before the publication of the 2 CVID reports. (4,5) Retrospectively, it is possible that the authors would not have considered LT in this patient because of the poor and complicated reported results of LT in CVID patients described in these 2 articles. Nevertheless, it was too late at that time, and in view of the complicated first posttransplant year of our patient (but without liver graft issues), tacrolimus withdrawal was attempted with success.…”