Liver Transplantation in the Pig

Hunt, P. S.; Cocks, Julian; W, De Boer; Dennis, P. M.; Gordon, Elizabeth M.; Jablonski, Paula; Sali, Adnan; Tannenberg, Alf M.; Yoffa, D. E.; Jm, Watts

doi:10.5694/j.1326-5377.1970.tb49982.x

Cited by 12 publications

(7 citation statements)

References 9 publications

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“…This pattern has also been observed in experimental animals either when immunosuppression was not introduced or after discontinuation. 21,22 However, classical features of liver allograft rejection, as characterized by the triad of endotheliitis, portal tract inflammation, and bile duct damage, developed in a minority of patients only (4 of 18). More commonly when there was an increase in liver enzyme levels, the graft histology demonstrated moderate or severe portal tract inflammation, occasionally with features of a lobular hepatitis.…”

Section: Discussionmentioning

confidence: 99%

Defining the outcome of immunosuppression withdrawal after liver transplantation

et al. 1998

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Successful immunosuppression withdrawal should benefit the natural history of organ transplantation patients. To identify the clinical hazards of removing drug treatment and possible characteristics that predict a favorable outcome in long-term liver recipients, immunosuppression was withdrawn completely and the clinicopathological outcome documented in 18 liver recipients. Indication for transplantation, HLA matching, early rejection history, and presence of microchimerism were examined as predictors of outcome. Chimerism was determined by polymerase chain reaction-based examination for donor-specific HLA-DRB1 alleles and Y-gene-specific nucleotide sequences. At 3 years, 5 patients (28%) remained completely off immunosuppression; 12 patients (67%) experienced histological graft changes: acute rejection in 4, portal tract inflammation/ hepatitis in 7, and necrosis in 1. Hepatitis B or C viral infections did not account for the nonrejection patterns. Unmasking of systemic disorders occurred. Chimerism, demonstrated in 7 patients (39%), with skin the optimal tissue, was not associated with tolerance. Parameters associated with successful drug withdrawal were transplantation for non-immune-mediated liver disorders, fewer donorrecipient HLA A, B, and DR mismatches, and a low incidence of early rejection. Immunosuppression withdrawal is a feasible option in a proportion of selected liver recipients, but identification of tolerant patients remains imprecise. (HEPATOLOGY 1998;27:926-933.)

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Section: Discussionmentioning

confidence: 99%

Defining the outcome of immunosuppression withdrawal after liver transplantation

et al. 1998

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“…Fibrinoid necrosis of arterial walls was not seen. Both Hunt (1967) and his associates (1967b, 1969) noted that in some long-term survivors there was an increased amount of fibrous connective tissue in the portal tracts and interlobular septa and around the central veins. In 2 of Calne's animals there was slight fibroelastic thickening of some hepatic arteries.…”

Section: Untreated Porcine Hepatic Auograftsmentioning

confidence: 97%

“…A detailed description of the structural changes that occur in porcine hepatic allografts has been given by Hunt (1967). He found that shortly after transplantation there was only oedema of the interlobular septa, but that at about the fourth day mononuclear cells began infiltrating the portal areas and septa.…”

Section: Untreated Porcine Hepatic Auograftsmentioning

confidence: 99%

Pathology of Liver Transplantation

Porter

1969

Immunological Reviews

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“…Many of these porcine recipients first passed through one or more self-resolving rejection crises. 28,30,31 In the 1970s, the phenomenon of tolerance induced by the liver was demonstrated in untreated rats (see later discussion).…”

Section: Hepatic Tolerogenicitymentioning

confidence: 99%

The Mystique of Hepatic Tolerogenicity

Starzl¹,

Murase²,

Demetris³

et al. 2000

Semin Liver Dis

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the consequences of organ and bone marrow engraftment were mirror images. From these observations, it was proposed that the engraftment of all kinds of organs as well as bone marrow cells (BMC) involved host versus graft (HVG) and graft versus host (6VH) reactions with reciprocal induction of variable degrees of specific non-reactivity (tolerance). The maintenance of the tolerance was an active and ongoing process requiring the persistence of the trans-

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Liver Transplantation in the Pig

Cited by 12 publications

References 9 publications

Defining the outcome of immunosuppression withdrawal after liver transplantation

Defining the outcome of immunosuppression withdrawal after liver transplantation

Pathology of Liver Transplantation

The Mystique of Hepatic Tolerogenicity

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