Liver Transplantation: Indications

Neuberger, James

doi:10.1016/b978-1-4160-3256-4.50123-x

Cited by 3 publications

(3 citation statements)

References 60 publications

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“…The overall 1 year survival rate following liver transplantation for all indication which includes transplantation for end stage liver disease in non-fulminant, fulminant and those patients with HCC approaches 80% 49 50. Therefore there is a 10–20% mortality rate at 1 year following a liver transplant.…”

Section: Discussionmentioning

confidence: 99%

Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis

Silva

Hegab

Hyde

et al. 2008

Gut

461

302

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Section: Discussionmentioning

confidence: 99%

Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis

Silva

Hegab

Hyde

et al. 2008

Gut

461

302

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“…Liver transplantation (LT) remains the gold standard for the treatment of acute and chronic end‐stage liver disease 1, 2. As LT waiting lists grow longer, many transplant centers have started to pursue specific strategies to increase the donor pool (eg, innovations and technical improvements in transplantation as well as split liver transplantation, domino transplantation, and living donor transplantation) 3.…”

Section: Studies Assessing Recipient Outcomes After Lt With Grafts Frmentioning

confidence: 99%

Impact of reversible cardiac arrest in the brain-dead organ donor on the outcome of adult liver transplantation

et al. 2011

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Several donor and graft characteristics are associated with higher failure rates for deceased donor liver transplantation (LT). The influence of reversible cardiac arrest in the donor on these failure rates is unclear because of scarce and inconsistent data. The aim of this study was to determine whether reversible cardiac arrest in the donor could affect the early postoperative outcome of LT. From January 2008 to February 2010, 165 patients underwent LT, and they were retrospectively divided into 2 groups: a cardiac arrest group (34 patients who received grafts from donors who had experienced reversible cardiac arrest before organ procurement) and a control group (131 patients who received grafts from donors without a history of reversible cardiac arrest). The postoperative complications and the graft and recipient outcomes were prospectively recorded for all the patients. Graft failure was defined as death or the need for retransplantation within 90 days of LT. Donors in the cardiac arrest group displayed higher serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels than donors in the control group versus 42 IU/L (10-225 IU/L), P < 0.001; ALT: 73 (13-869) versus 29 IU/L (6-549 IU/L), P < 0.001]. However, no difference in the graft failure rates was found between the 2 groups (11.8% versus 8.4%, P ¼ 0.51). The biological parameters 5 and 7 days after LT and the peak AST/ALT levels were similar for the 2 groups. Furthermore, the 2 groups had similar graft and patient survival rates at the 6-month mark (87% and 88%, respectively). In conclusion, our study shows that brief and reversible cardiac arrest in organ donors does not affect post-LT allograft survival and function, even though liver function test values are higher for these donors. However, the risk of using these grafts needs to be balanced against the potential benefits for the recipients.

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“…Orthotopic liver transplantation is the only effective treatment for end‐stage liver disease [1,2]. While the number of patients awaiting liver transplantation has shown a steady rise over the last decade, there has been no corresponding increase in the organs available for transplantation.…”

Section: Introductionmentioning

confidence: 99%

The marginal liver donor an update

Attia

Silva

Mirza

2008

Transplant International

113

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The number of patients awaiting liver transplantation keeps steadily rising with no corresponding rise in suitable grafts for transplantation. There also is an increasing trend of patients dying or being taken off waiting lists because of deterioration while waiting for a transplant. Over the preceding years the use of marginal grafts in liver transplantation has been driven by the critical shortage of donor organs and by emerging data that their use has resulted in a favourable outcome. This review revisits the factors defining marginality of a graft, and the issues faced by transplant units in making the decision to use such a graft. It also looks at the innovations in transplantation geared towards increasing the donor pool and the resulting issues of matching marginal grafts to suitable recipients.

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Liver Transplantation: Indications

Cited by 3 publications

References 60 publications

Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis

Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis

Impact of reversible cardiac arrest in the brain-dead organ donor on the outcome of adult liver transplantation

The marginal liver donor an update

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