Liver Tumors in Rats Fed Thiourea or Thioacetamide

Miscellaneous Chemical Carcinogens: Chemical Constitution and Carcinogenic Activity

“…NH.CONH2 C OC2H5 XLVIII Fitzhugh and Nelson (1950) have found that this substance produces liver tumours in albino rats fed at dosage levels of 0.1 per cent and above. At 0 5 and 1 per cent, Dulcin retarded the growth rate, increased the mortality rate and produced dark red spleens.…”

“…Complete thyroidectomy prior to the administration of 2-acetylaminofluorene prevents the development of neoplasms of the liver; but tumours were observed in several other organs, the most frequently affected site being the meatus acousticus externus (Bielschowsky and Hall, 1953). (It should be noted that thyroid adenomata have also been observed following prolonged administration of goitrogenic substances (allyl thiourea and thiourea) alone (Bielschowsky, 1945a;Purves and Griesbach, 1947), and the prolonged administration of thiourea and of thioacetamide is also reported to produce liver tumoufrs (Fitzhugh and Nelson, 1948;Dupta, 1955). )…”

Portal-Systemic Encephalopathy in Emergency Treatment of Cirrhosis and Bleeding Esophageal Varices

“…The results of this study served as the basis for the subsequent use of reduced-caliber PCS in the treatment of variceal bleeding (Sarfeh & Rypins, 1994;Zervox et al, 1998). I n a d d i t i o n t o a m m o n i a , c h r o n i c l i v e r f a i l ure and portal-systemic shunting result in increased blood and brain concentrations of manganese (López-Novoa, 1988;Fitzhugh & Nelson, 1948;Dashti et al, 1989;& Nuber et al, 1980). Manganese is neurotoxic, affecting both neuronal and astrocytic integrity.…”

Effects of 1-Morpholinoacetyl-2-Methyl-3-Phenyl-4-Oxo-1,2, 3, 4-Tetrahydro Quinazoline Hydrochloride (Hq-275) on ?-Naphtyl Isothiocyanate- And/or Thioacetamide-Induced Liver Damage in Rats

“…Furthermore, in respect to bilirubin, rats treated with ANIT produced a hepatic bile stagnation, that is obstructive icterus, due to occlusion of the common bile duct by calculus and/or cancer of the pancreas and a mild centrilobular necrosis border ing ballooning. On the other hand, hepatic changes by TAA , which result in a similar lesion can be produced by feeding thiourea, are histologically sinusoidal congestion , hy dropic swelling and increased mitosis (5,6). Moreover , decrease of hepatic protein, lipids esterase activity, and increase in hepatic water content and Al-P activity developments are recognized histochemically (7).…”