2021
DOI: 10.1016/j.bbadis.2021.166121
|View full text |Cite
|
Sign up to set email alerts
|

Liver X receptors and liver physiology

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

1
17
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 26 publications
(18 citation statements)
references
References 156 publications
1
17
0
Order By: Relevance
“…Although LXR binding is not required for the basal expression of these genes, prior studies have shown that LXRs mediate induction of these genes in liver in response to synthetic LXR ligand or cholesterol diet challenge ( 7 , 8 , 45 ). This separation is consistent with a primary role for hepatic LXRs in the basal state in fatty acid metabolism and roles in both fatty acid and cholesterol metabolism for LXR in the setting of high ligand concentration ( 23 ).…”
Section: Discussionsupporting
confidence: 79%
See 1 more Smart Citation
“…Although LXR binding is not required for the basal expression of these genes, prior studies have shown that LXRs mediate induction of these genes in liver in response to synthetic LXR ligand or cholesterol diet challenge ( 7 , 8 , 45 ). This separation is consistent with a primary role for hepatic LXRs in the basal state in fatty acid metabolism and roles in both fatty acid and cholesterol metabolism for LXR in the setting of high ligand concentration ( 23 ).…”
Section: Discussionsupporting
confidence: 79%
“…In the absence of excess dietary cholesterol, the primary consequences of LXR deletion in liver are perturbations in fatty acid and phospholipid metabolism ( 21 , 22 ). Many studies have used synthetic agonists such as GW3965 and T0901317 as tools to investigate the role of LXRs in hepatic gene expression ( 23 ). Activation of LXRs with synthetic agonist improves atherosclerosis and glucose tolerance, but also increases hepatic lipogenesis ( 24 26 ).…”
mentioning
confidence: 99%
“…The results of lipidomics showed that the CE (24:1) content in the serum of HUA rats was significantly increased. The liver contains the most abundant cholesteryl ester hydrolase (CEH), so it is the main organ of cholesterol ester metabolism [ 45 ]. The abnormal improvement of serum CE (24:1) levels in HUA rats suggests that cholesterol ester metabolism in the liver may be affected under high serum UA environment.…”
Section: Discussionmentioning
confidence: 99%
“…Their target genes have key roles in both embryonic development and adult homeostasis, and they are collectively implicated in a vast majority, if not all, of the biological processes of the body [ 11 , 17 ]. The hepatic roles of several of these receptors have been reviewed recently and, therefore, will not be discussed herein [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”
Section: Introductionmentioning
confidence: 99%