Livestock-associated methicillin-resistant Staphylococcus aureus in inpatients: a snapshot from an Italian hospital

Characterization of resistance and virulence factors in livestock-associated methicillin-resistant Staphylococcus aureus

“…A previous study 9 reported a higher prevalence of SCCmec gene cassette type V compared to type I among LA-MRSA strains, diverging from our findings. A study from Greece identified SCCmec type V elements in both human and LA-MRSA isolates 7 .…”

“…Virulence factors like toxic shock syndrome toxin ( tsst ) and Panton-Valentine leukocidin ( PVL ) significantly impact MRSA pathogenicity. The tetracycline resistance gene tetM is notably prevalent in MDR MRSA strains, adding complexity to antibiotic resistance patterns 9 . Recognizing MRSA as an important pathogen, the World Health Organization (WHO) acknowledges its propensity to acquire AMR determinants, often associated with a diverse array of virulence factors.…”

“…Biofilm activities involving Microbial Surface Components Recognizing Adhesive Matrix Molecules (MSCRAMMs) and regulated by the icaABCD operon contribute to the prevalence of S. aureus in animal-derived products 3 . While research on LA-MRSA and occupational risks is extensive 9 , Nigeria needs more comprehensive insights into its molecular traits. This study in Edo, Nigeria, delves into LA-MRSA's role in MRSA epidemiology in cows, characterizing strains through antimicrobial testing, genetic element examination, and virulence profiling.…”

Rapid spread of a novel NDM-producing clone of Klebsiella pneumoniae CC147, Northern Italy, February to August 2023

“…From January to August 2023, 117 isolates of NDMproducing Kp were collected at OSM from 66 patients. Considering the first isolate of NDM-producing Kp for each patient, we performed whole genome sequencing of 66 isolates, using Illumina reads as in [5]. In addition, we sequenced the genomes of eight NDMproducing Kp isolated from patients admitted to Ospedale Civile di Voghera, a 200-bed hospital in the Pavia province (ca 30 km from Pavia), belonging to the Pavia Health Authority Unit (Pavia-HAU).…”

Combining Genome Surveillance and Metadata To Characterize the Diversity of Staphylococcus aureus Circulating in an Italian Hospital over a 9-Year Period

“… S. aureus was the first species for which population-scale genome sequencing was exploited to understand local and global epidemiology of high-risk clones ( 17 ). Subsequent studies helped to determine which clones were more frequent in specific settings and worldwide ( 18 – 20 ) and in environments ( 21 , 22 ). These population-wide studies provide important baseline data and complement studies focusing on specific lineages at global or local levels ( 23 , 24 ).…”