This work presents some ambitious perspectives on how Systems Chemistry can contribute to developing the quite new research line of Chemical Artificial Intelligence (CAI). CAI refers to the efforts of devising liquid chemical systems mimicking some performances of biological and human intelligence, which ultimately emerge from wetware. The CAI systems implemented so far assist humans in making decisions. However, such CAI systems lack autonomy and cannot substitute humans. The development of autonomous chemical systems will allow the colonization of the molecular world with remarkable repercussions on human well‐being. As a beneficial side effect, this research line will help establish a deeper comprehension of the mesmerizing phenomenon of the origin of life on Earth and how cognitive capabilities emerge at a basic physico‐chemical level.