Living Donor Liver Transplantation for Imatinib‐Resistant Gastrointestinal Stromal Tumor Liver Metastases: A New Therapeutic Option in Transplant Oncology

Benítez, Carlos; Inzunza, Martín; Riveros, Sergio; Rivas, Violeta; Garrido, Marcelo; Dib, M.; Barrera, Francisco; Arab, Juan Pablo; Torres, Javiera; Cortínez, Luis Ignacio; Briceño, Eduardo; Guerra, Juan Francisco; Fernandes, Eduardo de Souza Martins; Martínez, Jorge

doi:10.1002/lt.25769

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Si además agregamos a los pacientes que se enlistan por otros tipos de cáncer, este porcentaje es aun mayor 7,8 . En nuestro centro, la Red de Salud UC-CHRISTUS, tenemos experiencia con otras indicaciones oncológicas de TH que incluyen el hepatoblastoma en niños, las metástasis hepáticas irresecables de TNE y un caso de metástasis hepáticas de una variante de GIST 9,10 .…”

Section: Concepto De "Oncología De Trasplante"unclassified

Trasplante hepático por metástasis hepáticas irresecables de cáncer colorrectal: revisión de la literatura

et al. 2022

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In Chile, colorectal cancer ranks third in incidence and fifth in mortality. Half of these patients have liver metastases at the diagnosis, and only 30% of them are resectable. Despite the development of many complex hepatobiliary procedures to achieve the total resection of metastases, the long-term survival with these techniques is not good. Liver transplantation is an alternative to treat unresectable liver metastasis from colorectal cancer with a good outcome. Several prognostic scores allow the selection of patients with good tumor biology. These patients have better overall and disease-free survival after liver transplantation. The use of immunosuppressive treatment doesn't increase recurrence, and even the pattern of tumor growth is slower in liver transplant recipients. The purpose of this review is to summarize the current evidence in this topic and to highlight the need for a formal protocol for liver transplantation for unresectable colorectal liver metastases, using living donors or marginal grafts to avoid competition with the rest of the national waiting list.

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Section: Concepto De "Oncología De Trasplante"unclassified

Trasplante hepático por metástasis hepáticas irresecables de cáncer colorrectal: revisión de la literatura

et al. 2022

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“…The clinical features of the present case report of a female patient with a metastatic gastric GIST, disease ‐free for 4 years since LT, are identical to those seen in SDH‐ deficient GIST. A recent report by Benítez et al describes a similar case of a female patient with a metastatic GIST, called KIT/PDGFRA WT, disease free for 42 months after LT from a living donor 5 …”

Section: Figurementioning

confidence: 99%

Letter to the editor concerning “Liver transplantation for metastatic wild-type gastrointestinal stromal tumor in the era of molecular targeted therapies: Report of a first case"

Nannini

Pantaleo

2020

American Journal of Transplantation

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“…We read with great interest the article by Benítez et al, (1) which describes a case of a gastric KIT and platelet-derived growth factor receptor alfa (PDGFRA) wild-type (WT) gastrointestinal stromal tumor (GIST) with liver metastases in a young woman who underwent living donor liver transplantation (LT). The approach of LT in GIST is extremely interestingly, but it requires a lot of attention and caution on which message is sent to the scientific community and patients.…”

Section: To the Editormentioning

confidence: 99%