Living Donor Liver Transplantation for Acute Liver Failure: A 10-Year Experience in a Single Center

Live Donor Liver Transplantation: A Valid Alternative for Critically Ill Patients Suffering From Acute Liver Failure

“…Reports on LDLT for the treatment of ALF in adult patients come mainly from Asia (1,(9)(10)(11)(12)(13)(14). Data regarding LDLT for the treatment of ALF form Western centers is scarce.…”

“…To the best of our knowledge, evidence supporting the use of LDLT to treat ALF in adult patients is scarce in the Western Hemisphere (8), while few reports are available from Asian centers (1,(9)(10)(11)(12)(13)(14). Herein, we report a single center experience of adult patients suffering from ALF who were treated at our institution with LDLT.…”

Feasibility of adult-to-adult living donor liver transplantation for acute liver failure

“…Because the opportunity to perform deceased donor liver transplantation is almost not an option in Japan, possible donor candidates were transferred with an ALF patient to our center and underwent donor evaluation, including a history and physical, blood work, sonogram, and computed tomography volumetry, on the day of arrival. 2,3 There was no donor mortality in our series. Nonliver-associated complications occurred in 12 donors (23%), including peptic ulcer (n ϭ 2), gastric stasis (n ϭ 3), wound problem (n ϭ 3), alopecia (n ϭ 1), and temporary ulnar nerve palsy (n ϭ 1).…”

“…They described 2 concerns in applying LDLT for ALF: appropriate donor evaluation during the rapid evolution of ALF and the outcome of the critically ill recipients receiving a partial graft. Because we have reported the largest adult-toadult LDLT series in the literature, 2 comments on their report with an update of our series are herein described.…”

Outcome of Acute Liver Failure Due to Hepatitis a Treated With Medical Management

“…+The patients with grade III hepatic encephalopathy have a transplant free survival (66.6% in our study) comparable to the success rates reported from various high volume living donor liver transplantation centres (1 year post-transplant survival rate 59-88%). [8][9][10][11][12] The estimated risk of mortality and morbidity currently associated with live donor hepatectomy is 0.4% and 35%, respectively. [13] These two factors need to be considered while making treatment decisions.…”