Living Donor Liver Transplantion for Primary Biliary Cirrhosis with Autoimmune Hemolytic Anemia: A Case Report

Kaibori, Masaki; Uchida, Yoichiro; Ishizaki, Morihiko; Saito, Takamichi; Hirohara, Junko; Kishimoto, Yuji; Uemura, Yoshiko; Tanaka, Kōichi; Kamiyama, Yasuo

doi:10.1007/s10620-006-9396-6

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Secondary causes seem to be reported more often in children than in adults: viral infections (7), autoimmune disorders, immune deficiency syndromes and lymphoproliferative diseases have all been associated with AIHA (1). However, there are only scarce data on AIHA after solid organ transplantation and the exact prevalence is not known (8)(9)(10)(11)(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of mixed-type autoimmune hemolytic anemia with rituximab in a child following liver transplantation

Haller

Hind

Height

et al. 2010

Pediatric Transplantation

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Section: Discussionmentioning

confidence: 99%

Successful treatment of mixed-type autoimmune hemolytic anemia with rituximab in a child following liver transplantation

Haller

Hind

Height

et al. 2010

Pediatric Transplantation

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“…Only UDCA therapy for PBC patients with mild AIHA had a successful report [8], so in mild cases this method could be considered with regular blood cell counts to monitor response. Although Kaibori et al [5] provided a successful case that could confirm liver transplantation and splenectomy is a curative therapy to PBC-related AIHA, as Retana et al [6] reported, hemolysis also occurred after liver transplantation despite well-functioning graft. So immunosuppressant prescribed after liver transplantation and splenectomy would not avoid further production of anti-erythrocyte antibodies in all of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…However, the association between PBC and AIHA is uncommon. To our knowledge, only fourteen such case reports have been described in the world literature [4,5,6,7,8,9,10,11,12,13,14,15,16,17]. We now describe the cases of three such patients.…”

Section: Introductionmentioning

confidence: 87%

Primary Biliary Cirrhosis-Related Autoimmune Hemolytic Anemia: Three Case Reports and Review of the Literature

Tian¹,

Wang²,

Liu³

et al. 2009

Case Rep Gastroenterol

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The association between primary biliary cirrhosis (PBC) and autoimmune hemolytic anemia (AIHA) is uncommon; only fourteen such case reports have been described. In this report, three patients who developed AIHA on the basis of PBC underwent successful therapy with corticosteroids and ursodeoxycholic acid (UDCA). Patient 3 was more complicated, suffering from PBC, Evans syndrome, Sjögren syndrome and Klinefelter syndrome simultaneously. This has not previously been reported in the world literature. Review of all fifteen cases showed that there is a prominent occurrence sequence that AIHA might take place on the basis of PBC. With sufficient doses of corticosteroids or immunosuppressant therapy, besides hemolysis under effective control, liver function also improved. According to the criteria of secondary AIHA, we may call them PBC-related AIHA. Thus, patients with PBC with serum bilirubin levels rising suddenly should undergo screening for associated hemolysis. Recommended treatment for PBC-related AIHA includes sufficient doses of corticosteroids to control the hemolysis in the acute phase, and immunosuppressant or adequate dose of UDCA to maintain therapy. These case reports have been increasing in recent years, so further reserch is needed to illustrate the incidence and natural courses of these two organ-specific autoimmune diseases.

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“…The association between PBC and warm autoimmune hemolytic anemia (wAIHA) is quite rare. To our knowledge, only 20 case reports have been described in the literature . Here we reported a case of PBC‐associated wAIHA.…”

Section: Introductionmentioning

confidence: 86%

Primary biliary cholangitis associated with warm autoimmune hemolytic anemia

González-Moreno

Martínez-Cabriales

Cruz-Moreno

et al. 2016

J of Digest Diseases

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There are many autoimmune diseases associated with primary biliary cholangitis (PBC), known as primary biliary cirrhosis; however, the association between PBC and warm autoimmune hemolytic anemia (wAIHA) has rarely been reported. It is documented that hemolysis is present in over 50% of the patients with chronic liver disease, regardless of the etiologies. Due to the clear and frequent relationship between PBC and many autoimmune diseases, it is reasonable to suppose that wAIHA may be another autoimmune disorder seen in association with PBC. Here we reported a 53-year-old female patient diagnosed with wAIHA associated with PBC.

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Living Donor Liver Transplantion for Primary Biliary Cirrhosis with Autoimmune Hemolytic Anemia: A Case Report

Cited by 7 publications

References 5 publications

Successful treatment of mixed-type autoimmune hemolytic anemia with rituximab in a child following liver transplantation

Successful treatment of mixed-type autoimmune hemolytic anemia with rituximab in a child following liver transplantation

Primary Biliary Cirrhosis-Related Autoimmune Hemolytic Anemia: Three Case Reports and Review of the Literature

Primary biliary cholangitis associated with warm autoimmune hemolytic anemia

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