Living high - training low model applied to C57BL/6J mice: Effects on physiological parameters related to aerobic fitness and acid-base balance

Scariot, Pedro Paulo Menezes; Papoti, Marcelo; Polisel, Emanuel Elias Camolese; Orsi, Juan Bordon; Ginkel, Paul R. van; Prolla, Tomas A.; Manchado-Gobatto, Fúlvia de Barros; Gobatto, Cláudio Alexandre

doi:10.1016/j.lfs.2023.121443

Life Sciences

2023

DOI: 10.1016/j.lfs.2023.121443

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Living high - training low model applied to C57BL/6J mice: Effects on physiological parameters related to aerobic fitness and acid-base balance

Pedro Paulo Menezes Scariot

Marcelo Papoti

Emanuel Elias Camolese Polisel

et al.

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2024

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Living High-Training Low on Mice Bone Parameters Analyzed through Complex Network Approach

Beck,

Scariot,

Papoti

et al. 2024

Int J Sports Med

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The aim of this study was to investigate the effect of 8 weeks of hypoxic exposition and physical training on healthy mice femur outcomes analyzed through conventional statistic and complex networks. The mice were divided into four groups, subjected to physical training (T; 40 min per day at 80% of critical velocity intensity) or not (N), exposed to hypoxic environment (“Living High-Training Low” model – LHTL; 18 h per day, FIO2=19.5%; Hyp) or not (Nor). The complex network analysis performed interactions among parameters using values of critical “r” of 0.5 by Pearson correlations to edges construction, with Fruchterman-Reingold layout adopted for graph visualization. Pondered Degree, Betweenness, and Eigenvector metrics were chosen as centrality metrics. Two-way ANOVA, t-test and Pearson correlation were used with P<0.05. Femur phosphorus of T-Hyp was higher than all other groups (P<0.05) and correlated with bone density (r=0.65; P=0.042), bone mineral density (r=0.67; P=0.034) and% of mineral material (r=0.66, P=0.038). Overall, the complex network demonstrated improvements in bone volume, % of mineral material, bone density, and bone mineral density for T-Hyp over other groups. Association of physical training and hypoxia improved bone quality for healthy mice.

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Living High-Training Low on Mice Bone Parameters Analyzed through Complex Network Approach

Beck,

Scariot,

Papoti

et al. 2024

Int J Sports Med

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show abstract

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Living high - training low model applied to C57BL/6J mice: Effects on physiological parameters related to aerobic fitness and acid-base balance

Cited by 1 publication

References 153 publications

Living High-Training Low on Mice Bone Parameters Analyzed through Complex Network Approach

Living High-Training Low on Mice Bone Parameters Analyzed through Complex Network Approach

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