Living polymerization of α-amino acid-<i>N</i>-carboxyanhydrides

Deming, Timothy J.

doi:10.1002/1099-0518(20000901)38:17<3011::aid-pola10>3.0.co;2-z

Cited by 262 publications

(212 citation statements)

References 31 publications

Supporting

Mentioning

205

Contrasting

Unclassified

Order By: Relevance

“…In the synthetic approaches, stepwise solid-phase polypeptide synthesis (SPPS) [45,46], native chemical ligation (NCL) [47] or ring opening polymerisation of α-amino-N-carboxyanhydrides (NCAs) [48][49][50] can be included. Those techniques are mainly based on the use of amino acids or their derivatives as monomers and are particularly useful in the design of hybrid architectures that combine sequences of peptidic and non-peptidic nature.…”

Section: Polypeptide Design and Synthesismentioning

confidence: 99%

“…There is a growing interest in developing synthetic strategies that could overcome the limitations of the genetically encoded synthesis to produce polypeptides with similar control of size and uniformity [48][49][50]. Among the advantages of the synthetic approaches, the following can be pointed out:…”

Section: Synthetic Approachesmentioning

confidence: 99%

“…The first NCA [72][73][74] were synthesised by Leuchs in 1906. Since then, a plethora of polypeptides has been created due to the variety of natural and non-natural amino acids and the versatility of the polymerisation method, as it has been reviewed in the following excellent literature [48][49][50].…”

Section: Ring-opening Polymerisation (Rop) Of α-Amino Acid N-carboxyamentioning

confidence: 99%

See 2 more Smart Citations

Peptide-Based Polymer Therapeutics

2014

View full text Add to dashboard Cite

Abstract:Polypeptides are envisaged to achieve a major impact on a number of different relevant areas such as biomedicine and biotechnology. Acquired knowledge and the increasing interest on amino acids, peptides and proteins is establishing a large panel of these biopolymers whose physical, chemical and biological properties are ruled by their controlled sequences and composition. Polymer therapeutics has helped to establish these polypeptide-based constructs as polymeric nanomedicines for different applications, such as disease treatment and diagnostics. Herein, we provide an overview of the advantages of these systems and the main methodologies for their synthesis, highlighting the different polypeptide architectures and the current research towards clinical applications.

show abstract

Section: Polypeptide Design and Synthesismentioning

confidence: 99%

Section: Synthetic Approachesmentioning

confidence: 99%

Section: Ring-opening Polymerisation (Rop) Of α-Amino Acid N-carboxyamentioning

confidence: 99%

See 1 more Smart Citation

Peptide-Based Polymer Therapeutics

2014

View full text Add to dashboard Cite

show abstract

“…In recent decades, improved methods in chemical synthesis have made possible the preparation of increasingly complex copolypeptide sequences of controlled molecular weight that display properties far superior to ill-defined homopolypeptides [5]. Furthermore, block copolypeptides, that combine different structural and functional peptide elements, have been prepared and begin to mimic some of the complexities of proteins [6].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Self-Assembly of Well-Defined Block Copolypeptides via Controlled NCA Polymerization

Deming

2013

Hierarchical Macromolecular Structures: 60 Years After the Staudinger Nobel Prize II

Self Cite

View full text Add to dashboard Cite

“…The preparation of polypeptides through N-carboxy anhydrides (NCA) polymerizations has been employed since the 1950s 22 but has recently attracted increased interest due to the successful efforts of several groups to improve the control over the NCA polymerization through reduced temperature, [23][24][25] reduced pressure, 24,26,27 or the employment of specific initiators. 14,[28][29][30][31][32][33][34][35][36] Hence, polypeptides with narrow polydispersities, defined architectures, and end-groups are now accessible via NCA polymerization opening new avenues for material design. One important aspect that has yet to be explored in detail is the understanding of NCA copolymerization both in terms of reaction kinetics and chain microstructure.…”

Section: Introductionmentioning

confidence: 99%

Terpolymerization kinetics of amino acid N‐carboxy anhydrides

Zelzer

Heise

2014

J. Polym. Sci. Part A: Polym. Chem.

View full text Add to dashboard Cite

Based on their versatility with respect to amino acid type and sequence, polypeptides have become attractive for a number of biological applications such as drug delivery, biomineralization, and drugs. N-carboxy anhydride (NCA) polymerization is a convenient way to rapidly prepare high-molecular weight polypeptides with good control over molecular weight and polydispersity. However, the kinetics of the incorporation of NCA monomers into copolypeptides during random copolymerization are poorly understood. Here, kinetic data is presented that allows insight into the NCA polymerization of a terpolymer composed of three commercially relevant amino acids, namely, glutamic acid, lysine, and tyrosine. Furthermore, kinetic data and copolymerization parameters from the copolymerization of binary mixtures of these three amino acid NCAs is used to make predictions of the terpolymer composition. This study provides access to the information necessary to prepare functional copolypeptides with better-defined sequence architecture that will be essential for the future development of polypeptide-based materials.

show abstract

Living polymerization of α-amino acid-N-carboxyanhydrides

Cited by 262 publications

References 31 publications

Peptide-Based Polymer Therapeutics

Peptide-Based Polymer Therapeutics

Synthesis and Self-Assembly of Well-Defined Block Copolypeptides via Controlled NCA Polymerization

Terpolymerization kinetics of amino acid N‐carboxy anhydrides

Contact Info

Product

Resources

About